High-dose escitalopram in the treatment of binge-eating disorder with obesity: a placebo-controlled monotherapy trial.

Published

Journal Article

OBJECTIVE: The purpose of this study was to evaluate the efficacy and safety of high-dose escitalopram in the treatment of binge-eating disorder (BED) associated with obesity. METHOD: Forty-four outpatients with BED by DSM-IV criteria and obesity were randomized to receive either escitalopram (N = 21) or placebo (N = 23) in a 12-week, double-blind, flexible dose (10-30 mg/day) study. RESULTS: In the primary analysis, escitalopram (mean dose 26.5 mg/day) and placebo had similar rates of reduction of binge episodes, binge days and obsessive-compulsive symptoms of BED. However, escitalopram was associated with statistically significant reductions in weight, body mass index (BMI), and global severity of illness scores. In a secondary analysis, escitalopram was associated with statistically significant reductions in frequency of binge episodes and binge days, weight, BMI and severity of illness, but not in obsessive-compulsive symptoms of BED. No changes in metabolic variables, including measures of ghrelin and leptin, were observed. High-dose escitalopram was well tolerated. CONCLUSION: High-dose escitalopram was not efficacious in reducing obsessive-compulsive symptoms of BED, but was efficacious in reducing weight and global severity of illness. No definitive conclusions about its efficacy in reducing binge-eating frequency could be drawn due to limitations related to statistical power.

Full Text

Duke Authors

Cited Authors

  • Guerdjikova, AI; McElroy, SL; Kotwal, R; Welge, JA; Nelson, E; Lake, K; Alessio, DD; Keck, PE; Hudson, JI

Published Date

  • January 2008

Published In

Volume / Issue

  • 23 / 1

Start / End Page

  • 1 - 11

PubMed ID

  • 18058852

Pubmed Central ID

  • 18058852

Electronic International Standard Serial Number (EISSN)

  • 1099-1077

Digital Object Identifier (DOI)

  • 10.1002/hup.899

Language

  • eng

Conference Location

  • England