Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.

Journal Article (Journal Article)

Apolipoprotein (apo) A-IV is an anorexigenic gastrointestinal peptide that is also synthesized in the hypothalamus. The goal of these experiments was to determine whether apo A-IV interacts with the central melanocortin (MC) system in the control of feeding. The third ventricular (i3vt) administration of a subthreshold dose of apo A-IV (0.5 microg) potentiated i3vt MC-induced (metallothionein-II, 0.03 nmol) suppression of 30-min feeding in Long-Evans rats. A subthreshold dose of the MC antagonist (SHU9119, 0.1 nmol, i3vt) completely attenuated the anorectic effect of i3vt apo A-IV (1.5 microg). The i3vt apo A-IV significantly elevated the expression of c-Fos in neurons of the paraventricular nucleus of the hypothalamus, but not in the arcuate nucleus or median eminence. In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate.

Full Text

Duke Authors

Cited Authors

  • Gotoh, K; Liu, M; Benoit, SC; Clegg, DJ; Davidson, WS; D'Alessio, D; Seeley, RJ; Tso, P; Woods, SC

Published Date

  • January 2006

Published In

Volume / Issue

  • 290 / 1

Start / End Page

  • R202 - R207

PubMed ID

  • 16166201

International Standard Serial Number (ISSN)

  • 0363-6119

Digital Object Identifier (DOI)

  • 10.1152/ajpregu.00502.2005


  • eng

Conference Location

  • United States