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Experimental demonstration of error recovery in an integrated cyberphysical digital-microfluidic platform

Publication ,  Conference
Hu, K; Ibrahim, M; Chen, L; Li, Z; Chakrabarty, K; Fair, R
Published in: IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings
December 4, 2015

Digital (droplet-based) microfluidics enables the integration of fluid-handling operations and reaction-outcome detection. Despite these benefits, defects and erroneous fluidic operations continue to be major barriers to the adoption and deployment of these devices. We describe the first practical and fully integrated cyberphysical error-recovery system that can be implemented in real time on a field-programmable gate array (FPGA). The hardware-Assisted solution is based on an error dictionary containing the error-recovery plans for various anticipated errors. The dictionary is computed and stored in FPGA memory before the start of the biochemical experiment. Errors in droplet operations on the digital microfluidic platform are detected using capacitive sensors, the test outcome is interpreted by control hardware, and corresponding error-recovery plans are triggered in real-Time. Experimental results are reported for a fabricated silicon device, and links to videos are provided for the first-ever experimental demonstration of real-Time error recovery in cyberphysical digital-microfluidic biochips using a hardware-implemented dictionary.

Duke Scholars

Published In

IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings

DOI

ISBN

9781479972333

Publication Date

December 4, 2015
 

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Hu, K., Ibrahim, M., Chen, L., Li, Z., Chakrabarty, K., & Fair, R. (2015). Experimental demonstration of error recovery in an integrated cyberphysical digital-microfluidic platform. In IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings. https://doi.org/10.1109/BioCAS.2015.7348390
Hu, K., M. Ibrahim, L. Chen, Z. Li, K. Chakrabarty, and R. Fair. “Experimental demonstration of error recovery in an integrated cyberphysical digital-microfluidic platform.” In IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings, 2015. https://doi.org/10.1109/BioCAS.2015.7348390.
Hu K, Ibrahim M, Chen L, Li Z, Chakrabarty K, Fair R. Experimental demonstration of error recovery in an integrated cyberphysical digital-microfluidic platform. In: IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings. 2015.
Hu, K., et al. “Experimental demonstration of error recovery in an integrated cyberphysical digital-microfluidic platform.” IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings, 2015. Scopus, doi:10.1109/BioCAS.2015.7348390.
Hu K, Ibrahim M, Chen L, Li Z, Chakrabarty K, Fair R. Experimental demonstration of error recovery in an integrated cyberphysical digital-microfluidic platform. IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings. 2015.

Published In

IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings

DOI

ISBN

9781479972333

Publication Date

December 4, 2015