The physics of protein self-assembly

Journal Article (Review;Journal)

Understanding protein self-assembly is important for many biological and industrial processes. Proteins can self-assemble into crystals, filaments, gels, and other amorphous aggregates. The final forms include virus capsids and condensed phases associated with diseases such as amyloid fibrils. Although seemingly different, these assemblies all originate from fundamental protein interactions and are driven by similar thermodynamic and kinetic factors. Here we review recent advances in understanding protein self-assembly through a soft condensed matter perspective with an emphasis on three specific systems: globular proteins, viruses, and amyloid fibrils. We conclude with a discussion of unanswered questions in the field.

Full Text

Duke Authors

Cited Authors

  • McManus, JJ; Charbonneau, P; Zaccarelli, E; Asherie, N

Published Date

  • April 1, 2016

Published In

Volume / Issue

  • 22 /

Start / End Page

  • 73 - 79

Electronic International Standard Serial Number (EISSN)

  • 1879-0399

International Standard Serial Number (ISSN)

  • 1359-0294

Digital Object Identifier (DOI)

  • 10.1016/j.cocis.2016.02.011

Citation Source

  • Scopus