Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.

Journal Article (Journal Article)

Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one-step ring-opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self-assembles into well-defined nanoparticles with tunable size.

Full Text

Duke Authors

Cited Authors

  • Liu, J; Pang, Y; Bhattacharyya, J; Liu, W; Weitzhandler, I; Li, X; Chilkoti, A

Published Date

  • August 2016

Published In

Volume / Issue

  • 5 / 15

Start / End Page

  • 1868 - 1873

PubMed ID

  • 27111757

Pubmed Central ID

  • PMC5279999

Electronic International Standard Serial Number (EISSN)

  • 2192-2659

International Standard Serial Number (ISSN)

  • 2192-2640

Digital Object Identifier (DOI)

  • 10.1002/adhm.201600230


  • eng