Recent advances in renal hypoxia: insights from bench experiments and computer simulations.


Journal Article (Review)

The availability of oxygen in renal tissue is determined by the complex interactions among a host of processes, including renal blood flow, glomerular filtration, arterial-to-venous oxygen shunting, medullary architecture, Na(+) transport, and oxygen consumption. When this delicate balance is disrupted, the kidney may become susceptible to hypoxic injury. Indeed, renal hypoxia has been implicated as one of the major causes of acute kidney injury and chronic kidney diseases. This review highlights recent advances in our understanding of renal hypoxia; some of these studies were published in response to a recent Call for Papers of this journal: Renal Hypoxia.

Full Text

Duke Authors

Cited Authors

  • Layton, AT

Published Date

  • July 2016

Published In

Volume / Issue

  • 311 / 1

Start / End Page

  • F162 - F165

PubMed ID

  • 27147670

Pubmed Central ID

  • 27147670

Electronic International Standard Serial Number (EISSN)

  • 1522-1466

International Standard Serial Number (ISSN)

  • 1931-857X

Digital Object Identifier (DOI)

  • 10.1152/ajprenal.00228.2016


  • eng