Acute treatment of benign gastric ulcer with once-daily bedtime dosing of cimetidine compared with placebo.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

This multicentre, double-blind study evaluated the efficacy of cimetidine 800 mg nocte compared to placebo for ulcer healing and pain relief in patients with endoscopically confirmed, benign gastric ulcers treated for up to 8 weeks. Cimetidine accelerated ulcer healing throughout the study. More cimetidine-treated patients (35 of 82, 43%) than placebo-treated patients (26 of 79, 33%) had healed ulcers after 4 weeks of therapy. Similarly, after 6 and 8 weeks of treatment, cimetidine continued to have superior healing rates, 76% (59 of 78, P = 0.02) and 91% (69 of 76, P = 0.02) heal rates for cimetidine recipients compared with 58% (42 of 73) and 74% (52 of 70) for placebo. For every week of the study except the second, a greater proportion of cimetidine-treated patients were free of daytime and night-time pain than placebo-treated patients; the differences were statistically significant for night-time pain. Adverse reaction profiles were similar for the cimetidine and placebo groups. In conclusion, cimetidine 800 mg nocte was comparably safe and significantly more effective than placebo in accelerating healing and relieving pain in the treatment of acute, benign gastric ulcer.

Full Text

Duke Authors

Cited Authors

  • Frank, WO; Young, MD; Palmer, R; Rockhold, F; Karlstadt, R; Mounce, W; O'Connell, S

Published Date

  • December 1989

Published In

Volume / Issue

  • 3 / 6

Start / End Page

  • 573 - 584

PubMed ID

  • 2518871

International Standard Serial Number (ISSN)

  • 0269-2813

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2036.1989.tb00250.x


  • eng

Conference Location

  • England