The efficacy of cimetidine in the treatment of "resistant" duodenal ulcers.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

In a prospective multicenter trial, 43 patients with acute duodenal ulcers unhealed after four weeks of treatment with an H2-receptor antagonist, ranitidine, were switched to treatment with another H2-receptor antagonist, cimetidine. Sixty-eight percent of the unhealed patients were successfully healed; of these patients, 81% were free of daytime pain and 89% were free of nighttime pain. Of those with residual pain, 71% and 50% showed improvement in daytime and nighttime pain severity, respectively. There were no unexpected adverse reactions reported or clinically significant changes in laboratory values measured during the study. It is concluded that cimetidine is highly effective both in healing duodenal ulcers unresponsive to ranitidine therapy and in providing continued relief of daytime and nighttime pain.

Full Text

Duke Authors

Cited Authors

  • Young, MD; Frank, WO; Karlstadt, RG; O'Connell, S; Palmer, RH; Rockhold, FW; Kogut, DG; Loiudice, TA; Orchard, JL; Stone, RC

Published Date

  • July 1, 1989

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 521 - 528

PubMed ID

  • 2673518

International Standard Serial Number (ISSN)

  • 0149-2918


  • eng

Conference Location

  • United States