Planar cell polarity and vertebrate organogenesis.


Journal Article (Review)

In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis.

Full Text

Duke Authors

Cited Authors

  • Karner, C; Wharton, KA; Carroll, TJ

Published Date

  • April 2006

Published In

Volume / Issue

  • 17 / 2

Start / End Page

  • 194 - 203

PubMed ID

  • 16839790

Pubmed Central ID

  • 16839790

International Standard Serial Number (ISSN)

  • 1084-9521

Digital Object Identifier (DOI)

  • 10.1016/j.semcdb.2006.05.003


  • eng

Conference Location

  • England