Skip to main content
Journal cover image

Comparison of Frequency of Frailty and Severely Impaired Physical Function in Patients ≥60 Years Hospitalized With Acute Decompensated Heart Failure Versus Chronic Stable Heart Failure With Reduced and Preserved Left Ventricular Ejection Fraction.

Publication ,  Journal Article
Reeves, GR; Whellan, DJ; Patel, MJ; O'Connor, CM; Duncan, P; Eggebeen, JD; Morgan, TM; Hewston, LA; Pastva, AM; Kitzman, DW
Published in: Am J Cardiol
June 15, 2016

Older patients with acute decompensated heart failure (ADHF) have persistently poor outcomes including frequent rehospitalization despite guidelines-based therapy. We hypothesized that such patients have multiple, severe impairments in physical function, cognition, and mood that are not addressed by current care pathways. We prospectively examined frailty, physical function, cognition, mood, and quality of life in 27 consecutive older patients with ADHF at 3 medical centers and compared these with 197 participants in 3 age-matched cohorts: stable heart failure (HF) with preserved ejection fraction (n = 80), stable HF with reduced ejection fraction (n = 56), and healthy older adults (n = 61). Based on Fried criteria, frailty was present in 56% of patients with ADHF versus 0 for the age-matched chronic HF and health cohorts. Patients with ADHF had markedly reduced Short Physical Performance Battery score (5.3 ± 2.8) and 6-minute walk distance (178 ± 102 m) (p <0.001 vs other cohorts), with severe deficits in all domains of physical function: balance, mobility, strength, and endurance. In the patients with ADHF, cognitive impairment (78%) and depression (30%) were common, and quality of life was poor. In conclusion, older patients with ADHF are frequently frail with severe and widespread impairments in physical function, cognition, mood, and quality of life that may contribute to their persistently poor outcomes, are frequently unrecognized, are not addressed in current ADHF care paradigms, and are potentially modifiable with targeted interventions.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

June 15, 2016

Volume

117

Issue

12

Start / End Page

1953 / 1958

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • United States
  • Time Factors
  • Stroke Volume
  • Severity of Illness Index
  • Quality of Life
  • Prospective Studies
  • Outpatients
  • Motor Activity
  • Morbidity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reeves, G. R., Whellan, D. J., Patel, M. J., O’Connor, C. M., Duncan, P., Eggebeen, J. D., … Kitzman, D. W. (2016). Comparison of Frequency of Frailty and Severely Impaired Physical Function in Patients ≥60 Years Hospitalized With Acute Decompensated Heart Failure Versus Chronic Stable Heart Failure With Reduced and Preserved Left Ventricular Ejection Fraction. Am J Cardiol, 117(12), 1953–1958. https://doi.org/10.1016/j.amjcard.2016.03.046
Reeves, Gordon R., David J. Whellan, Mahesh J. Patel, Christopher M. O’Connor, Pamela Duncan, Joel D. Eggebeen, Timothy M. Morgan, Leigh A. Hewston, Amy M. Pastva, and Dalane W. Kitzman. “Comparison of Frequency of Frailty and Severely Impaired Physical Function in Patients ≥60 Years Hospitalized With Acute Decompensated Heart Failure Versus Chronic Stable Heart Failure With Reduced and Preserved Left Ventricular Ejection Fraction.Am J Cardiol 117, no. 12 (June 15, 2016): 1953–58. https://doi.org/10.1016/j.amjcard.2016.03.046.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

June 15, 2016

Volume

117

Issue

12

Start / End Page

1953 / 1958

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • United States
  • Time Factors
  • Stroke Volume
  • Severity of Illness Index
  • Quality of Life
  • Prospective Studies
  • Outpatients
  • Motor Activity
  • Morbidity