Vorapaxar and diplopia: Possible off-target PAR-receptor mismodulation.


Journal Article (Review)

Vorapaxar, a novel antiplatelet thrombin PAR-1 inhibitor, has been evaluated in the successful TRA2P trial and the failed TRACER trial. The drug is currently approved for post myocardial infarction and peripheral artery disease indications with concomitant use of clopidogrel and/or aspirin. The FDA ruled that the vorapaxar safety profile is acceptable. However, both trials revealed excess diplopia (double vision) usually reversible after vorapaxar. The diplopia risk appears to be small (about 1 extra case per 1,000 treated subjects), but real. Overall, there were 10 placebo and 34 vorapaxar diplopia cases (p=0.018) consistent for TRACER (2 vs 13 cases; p=0.010) and for TRA2P (8 vs 21 cases; p=0.018). Hence, we review the FDA-confirmed evidence and discuss potential causes and implications of such a surprising adverse association, which may be related to off-target PAR receptor mismodulation in the eye.

Full Text

Duke Authors

Cited Authors

  • Serebruany, VL; Fortmann, SD; Rao, SV; Tanguay, J-F; Lordkipanidze, M; Hanley, DF; Can, M; Kim, MH; Marciniak, TA

Published Date

  • May 2, 2016

Published In

  • Thromb Haemost

Volume / Issue

  • 115 / 5

Start / End Page

  • 905 - 910

PubMed ID

  • 26887783

Pubmed Central ID

  • 26887783

Electronic International Standard Serial Number (EISSN)

  • 2567-689X

Digital Object Identifier (DOI)

  • 10.1160/TH15-11-0882


  • eng

Conference Location

  • Germany