Glucocorticoid signaling drives epigenetic and transcription factors to induce key regulators of human parturition.
Published online
Journal Article (Review)
Glucocorticoids are thought to play an important role in parturition. Two recent articles by Di Stefano et al. in the Archives and Wang et al. in this issue of Science Signaling reveal novel mechanisms by which glucocorticoid signaling can drive the epigenetic and transcriptional machinery to induce molecules involved in parturition, including the neuropeptide corticotropin-releasing hormone (CRH), the enzyme cyclooxygenase-2 (COX-2), and the autacoid hormone prostaglandin E2. These findings contribute to our understanding of how glucocorticoids may regulate human parturition.
Full Text
Duke Authors
Cited Authors
- Zannas, AS; Chrousos, GP
Published Date
- October 27, 2015
Published In
Volume / Issue
- 8 / 400
Start / End Page
- fs19 -
PubMed ID
- 26508787
Pubmed Central ID
- 26508787
Electronic International Standard Serial Number (EISSN)
- 1937-9145
Digital Object Identifier (DOI)
- 10.1126/scisignal.aad3022
Language
- eng
Conference Location
- United States