Glucocorticoid signaling drives epigenetic and transcription factors to induce key regulators of human parturition.

Journal Article (Journal Article;Review)

Glucocorticoids are thought to play an important role in parturition. Two recent articles by Di Stefano et al. in the Archives and Wang et al. in this issue of Science Signaling reveal novel mechanisms by which glucocorticoid signaling can drive the epigenetic and transcriptional machinery to induce molecules involved in parturition, including the neuropeptide corticotropin-releasing hormone (CRH), the enzyme cyclooxygenase-2 (COX-2), and the autacoid hormone prostaglandin E2. These findings contribute to our understanding of how glucocorticoids may regulate human parturition.

Full Text

Duke Authors

Cited Authors

  • Zannas, AS; Chrousos, GP

Published Date

  • October 27, 2015

Published In

Volume / Issue

  • 8 / 400

Start / End Page

  • fs19 -

PubMed ID

  • 26508787

Electronic International Standard Serial Number (EISSN)

  • 1937-9145

Digital Object Identifier (DOI)

  • 10.1126/scisignal.aad3022


  • eng

Conference Location

  • United States