Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy.

Journal Article (Journal Article;Review)

This review summarizes evidence from 2 lines of research previously thought to be unrelated: the unexpectedly positive results of TACT (Trial to Assess Chelation Therapy), and a body of epidemiological data showing that accumulation of biologically active metals, such as lead and cadmium, is an important risk factor for cardiovascular disease. Considering these 2 areas of work together may lead to the identification of new, modifiable risk factors for atherosclerotic cardiovascular disease. We examine the history of chelation up through the report of TACT. We then describe work connecting higher metal levels in the body with the future risk of cardiovascular disease. We conclude by presenting a brief overview of a newly planned National Institutes of Health trial, TACT2, in which we will attempt to replicate the findings of TACT and to establish that removal of toxic metal stores from the body is a plausible mechanistic explanation for the benefits of edetate disodium treatment.

Full Text

Duke Authors

Cited Authors

  • Lamas, GA; Navas-Acien, A; Mark, DB; Lee, KL

Published Date

  • May 24, 2016

Published In

Volume / Issue

  • 67 / 20

Start / End Page

  • 2411 - 2418

PubMed ID

  • 27199065

Pubmed Central ID

  • PMC4876980

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2016.02.066


  • eng

Conference Location

  • United States