Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer.

Journal Article (Journal Article;Review)

Immune surveillance is well recognized as an important mechanism to prevent development or progression of head and neck cancers. Head and neck cancer cells can escape the immune system through multiple mechanisms including development of tolerance in T cells and inhibition of T-cell-related pathways, generally referred to as checkpoint inhibitors. This article highlights advances in immuno-oncology treatment approaches in recurrent and metastatic head and neck squamous cell carcinoma. Clinical trials are discussed in detail, with an emphasis on response dynamics, oncologic efficacy, safety, and tolerability of checkpoint inhibitors. In addition, developing concepts and ongoing studies in this setting are also reviewed.

Full Text

Duke Authors

Cited Authors

  • Hashemi-Sadraei, N; Sikora, AG; Brizel, DM

Published Date

  • 2016

Published In

Volume / Issue

  • 35 /

Start / End Page

  • e277 - e282

PubMed ID

  • 27249733

Electronic International Standard Serial Number (EISSN)

  • 1548-8756

Digital Object Identifier (DOI)

  • 10.14694/EDBK_157801


  • eng

Conference Location

  • United States