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Scar burden assessed by Selvester QRS score predicts prognosis, not CRT clinical benefit in preventing heart failure event and death: A MADIT-CRT sub-study.

Publication ,  Journal Article
Wieslander, B; Loring, Z; Zareba, W; McNitt, S; Wagner, GS; Daubert, JP; Strauss, DG
Published in: J Electrocardiol
2016

BACKGROUND: There is a need for improved selection criteria for Cardiac Resynchronization Therapy (CRT). High myocardial scar burden has been associated with worse outcome in CRT patients. It is, however, unclear whether high scar burden ameliorates CRT clinical benefit or is merely predictive of prognosis in heart failure (HF) patients regardless of CRT implantation. We aimed to study the prognostic value of scar burden estimated by electrocardiographic Selvester QRS scoring in determining outcome in the Multicenter Automatic Defibrillator Implantation Trial – Cardiac Resynchronization Therapy (MADIT-CRT) population. METHOD: Selvester QRS scoring was performed on all 1820 ECGs of the MADIT-CRT population by a single observer. In both arms and in their respective LBBB subgroups, QRS score was analyzed in comparison to echocardiographic volumes and in relation to time to HF event or death using Cox Proportional Hazard Ratios. To determine effect on CRT clinical benefit, we tested for interaction between the effects of CRT assignment and QRS score on time to HF event or death. RESULTS: In the CRT-D arm, a significant correlation was found between higher continuous QRS score and less increase of left ventricular ejection fraction (LVEF) as well as less decrease of left ventricular end systolic volume (LVESV) (multivariate P-values: <0.001). QRS score was significantly correlated with HF event/death in the left bundle branch block (LBBB) subgroup (n=1037, multivariate HR 1.07 per point, P=0.046). Scar extent estimated by QRS scoring was neither predictive of CRT clinical benefit in the total study population (interaction P-value=0.25) nor in the LBBB subgroup (interaction P-value=0.86). CONCLUSION: High scar burden estimated by Selvester QRS score is predictive of adverse overall prognosis in LBBB patients regardless of CRT implantation. However, QRS score does not identify patients who benefit clinically from CRT-D compared to implantation of ICD only.

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Published In

J Electrocardiol

DOI

EISSN

1532-8430

Publication Date

2016

Volume

49

Issue

4

Start / End Page

603 / 609

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Predictive Value of Tests
  • Patient Selection
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Heart Conduction System
 

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Wieslander, B., Loring, Z., Zareba, W., McNitt, S., Wagner, G. S., Daubert, J. P., & Strauss, D. G. (2016). Scar burden assessed by Selvester QRS score predicts prognosis, not CRT clinical benefit in preventing heart failure event and death: A MADIT-CRT sub-study. J Electrocardiol, 49(4), 603–609. https://doi.org/10.1016/j.jelectrocard.2016.04.008
Wieslander, Björn, Zak Loring, Wojciech Zareba, Scott McNitt, Galen S. Wagner, James P. Daubert, and David G. Strauss. “Scar burden assessed by Selvester QRS score predicts prognosis, not CRT clinical benefit in preventing heart failure event and death: A MADIT-CRT sub-study.J Electrocardiol 49, no. 4 (2016): 603–9. https://doi.org/10.1016/j.jelectrocard.2016.04.008.
Wieslander B, Loring Z, Zareba W, McNitt S, Wagner GS, Daubert JP, et al. Scar burden assessed by Selvester QRS score predicts prognosis, not CRT clinical benefit in preventing heart failure event and death: A MADIT-CRT sub-study. J Electrocardiol. 2016;49(4):603–9.
Wieslander, Björn, et al. “Scar burden assessed by Selvester QRS score predicts prognosis, not CRT clinical benefit in preventing heart failure event and death: A MADIT-CRT sub-study.J Electrocardiol, vol. 49, no. 4, 2016, pp. 603–09. Pubmed, doi:10.1016/j.jelectrocard.2016.04.008.
Wieslander B, Loring Z, Zareba W, McNitt S, Wagner GS, Daubert JP, Strauss DG. Scar burden assessed by Selvester QRS score predicts prognosis, not CRT clinical benefit in preventing heart failure event and death: A MADIT-CRT sub-study. J Electrocardiol. 2016;49(4):603–609.
Journal cover image

Published In

J Electrocardiol

DOI

EISSN

1532-8430

Publication Date

2016

Volume

49

Issue

4

Start / End Page

603 / 609

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Predictive Value of Tests
  • Patient Selection
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Heart Conduction System