Adenocarcinoma of Mullerian origin: review of pathogenesis, molecular biology, and emerging treatment paradigms.

Published online

Journal Article

Traditionally, epithelial ovarian, tubal, and peritoneal cancers have been viewed as separate entities with disparate origins, pathogenesis, clinical features, and outcomes. Additionally, previous classification systems for ovarian cancer have proposed two primary histologic groups that encompass the standard histologic subtypes. Recent data suggest that these groupings no longer accurately reflect our knowledge surrounding these cancers. In this review, we propose that epithelial ovarian, tubal, and peritoneal carcinomas represent a spectrum of disease that originates in the Mullerian compartment. We will discuss the incidence, classification, origin, molecular determinants, and pathologic analysis of these cancers that support the conclusion they should be collectively referred to as adenocarcinomas of Mullerian origin. As our understanding of the molecular and pathologic profiling of adenocarcinomas of Mullerian origin advances, we anticipate treatment paradigms will shift towards genomic driven therapeutic interventions.

Full Text

Duke Authors

Cited Authors

  • Cobb, LP; Gaillard, S; Wang, Y; Shih, I-M; Secord, AA

Published Date

  • 2015

Published In

Volume / Issue

  • 2 /

Start / End Page

  • 1 -

PubMed ID

  • 27231561

Pubmed Central ID

  • 27231561

International Standard Serial Number (ISSN)

  • 2053-6844

Digital Object Identifier (DOI)

  • 10.1186/s40661-015-0008-z

Language

  • eng

Conference Location

  • England