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Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline.

Publication ,  Journal Article
Sohal, DPS; Mangu, PB; Khorana, AA; Shah, MA; Philip, PA; O'Reilly, EM; Uronis, HE; Ramanathan, RK; Crane, CH; Engebretson, A; Ruggiero, JT ...
Published in: J Clin Oncol
August 10, 2016

PURPOSE: To provide evidence-based recommendations to oncologists and others for the treatment of patients with metastatic pancreatic cancer. METHODS: American Society of Clinical Oncology convened an Expert Panel of medical oncology, radiation oncology, surgical oncology, gastroenterology, palliative care, and advocacy experts to conduct a systematic review of the literature from April 2004 to June 2015. Outcomes were overall survival, disease-free survival, progression-free survival, and adverse events. RESULTS: Twenty-four randomized controlled trials met the systematic review criteria. RECOMMENDATIONS: A multiphase computed tomography scan of the chest, abdomen, and pelvis should be performed. Baseline performance status and comorbidity profile should be evaluated. Goals of care, patient preferences, treatment response, psychological status, support systems, and symptom burden should guide decisions for treatments. A palliative care referral should occur at first visit. FOLFIRINOX (leucovorin, fluorouracil, irinotecan, and oxaliplatin; favorable comorbidity profile) or gemcitabine plus nanoparticle albumin-bound (NAB) -paclitaxel (adequate comorbidity profile) should be offered to patients with Eastern Cooperative Oncology Group performance status (ECOG PS) 0 to 1 based on patient preference and support system available. Gemcitabine alone is recommended for patients with ECOG PS 2 or with a comorbidity profile that precludes other regimens; the addition of capecitabine or erlotinib may be offered. Patients with an ECOG PS ≥ 3 and poorly controlled comorbid conditions should be offered cancer-directed therapy only on a case-by-case basis; supportive care should be emphasized. For second-line therapy, gemcitabine plus NAB-paclitaxel should be offered to patients with first-line treatment with FOLFIRINOX, an ECOG PS 0 to 1, and a favorable comorbidity profile; fluorouracil plus oxaliplatin, irinotecan, or nanoliposomal irinotecan should be offered to patients with first-line treatment with gemcitabine plus NAB-paclitaxel, ECOG PS 0 to 1, and favorable comorbidity profile, and gemcitabine or fluorouracil should be offered to patients with either an ECOG PS 2 or a comorbidity profile that precludes other regimens. Additional information is available at www.asco.org/guidelines/MetPC and www.asco.org/guidelineswiki.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 10, 2016

Volume

34

Issue

23

Start / End Page

2784 / 2796

Location

United States

Related Subject Headings

  • Symptom Assessment
  • Patient Care Team
  • Patient Care Planning
  • Pancreatic Neoplasms
  • Palliative Care
  • Pain Management
  • Oncology & Carcinogenesis
  • Humans
  • Evidence-Based Medicine
  • Communication
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sohal, D. P. S., Mangu, P. B., Khorana, A. A., Shah, M. A., Philip, P. A., O’Reilly, E. M., … Laheru, D. (2016). Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol, 34(23), 2784–2796. https://doi.org/10.1200/JCO.2016.67.1412
Sohal, Davendra P. S., Pamela B. Mangu, Alok A. Khorana, Manish A. Shah, Philip A. Philip, Eileen M. O’Reilly, Hope E. Uronis, et al. “Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline.J Clin Oncol 34, no. 23 (August 10, 2016): 2784–96. https://doi.org/10.1200/JCO.2016.67.1412.
Sohal DPS, Mangu PB, Khorana AA, Shah MA, Philip PA, O’Reilly EM, et al. Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2016 Aug 10;34(23):2784–96.
Sohal, Davendra P. S., et al. “Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline.J Clin Oncol, vol. 34, no. 23, Aug. 2016, pp. 2784–96. Pubmed, doi:10.1200/JCO.2016.67.1412.
Sohal DPS, Mangu PB, Khorana AA, Shah MA, Philip PA, O’Reilly EM, Uronis HE, Ramanathan RK, Crane CH, Engebretson A, Ruggiero JT, Copur MS, Lau M, Urba S, Laheru D. Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2016 Aug 10;34(23):2784–2796.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 10, 2016

Volume

34

Issue

23

Start / End Page

2784 / 2796

Location

United States

Related Subject Headings

  • Symptom Assessment
  • Patient Care Team
  • Patient Care Planning
  • Pancreatic Neoplasms
  • Palliative Care
  • Pain Management
  • Oncology & Carcinogenesis
  • Humans
  • Evidence-Based Medicine
  • Communication