Current therapies and future possibilities for drug development against liver-stage malaria.

Journal Article (Review;Journal Article)

Malaria remains a global public health threat, with half of the world's population at risk. Despite numerous efforts in the past decade to develop new antimalarial drugs to surmount increasing resistance to common therapies, challenges remain in the expansion of the current antimalarial arsenal for the elimination of this disease. The requirement of prophylactic and radical cure activities for the next generation of antimalarial drugs demands that new research models be developed to support the investigation of the elusive liver stage of the malaria parasite. In this Review, we revisit current antimalarial therapies and discuss recent advances for in vitro and in vivo malaria research models of the liver stage and their importance in probing parasite biology and the discovery of novel drug candidates.

Full Text

Duke Authors

Cited Authors

  • Raphemot, R; Posfai, D; Derbyshire, ER

Published Date

  • June 2016

Published In

Volume / Issue

  • 126 / 6

Start / End Page

  • 2013 - 2020

PubMed ID

  • 27249674

Pubmed Central ID

  • PMC4887158

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci82981


  • eng