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Current therapies and future possibilities for drug development against liver-stage malaria.

Publication ,  Journal Article
Raphemot, R; Posfai, D; Derbyshire, ER
Published in: The Journal of clinical investigation
June 2016

Malaria remains a global public health threat, with half of the world's population at risk. Despite numerous efforts in the past decade to develop new antimalarial drugs to surmount increasing resistance to common therapies, challenges remain in the expansion of the current antimalarial arsenal for the elimination of this disease. The requirement of prophylactic and radical cure activities for the next generation of antimalarial drugs demands that new research models be developed to support the investigation of the elusive liver stage of the malaria parasite. In this Review, we revisit current antimalarial therapies and discuss recent advances for in vitro and in vivo malaria research models of the liver stage and their importance in probing parasite biology and the discovery of novel drug candidates.

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Published In

The Journal of clinical investigation

DOI

EISSN

1558-8238

ISSN

0021-9738

Publication Date

June 2016

Volume

126

Issue

6

Start / End Page

2013 / 2020

Related Subject Headings

  • Plasmodium
  • Models, Biological
  • Malaria
  • Liver
  • Immunology
  • Humans
  • Drug Resistance
  • Drug Discovery
  • Drug Design
  • Antimalarials
 

Citation

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Raphemot, R., Posfai, D., & Derbyshire, E. R. (2016). Current therapies and future possibilities for drug development against liver-stage malaria. The Journal of Clinical Investigation, 126(6), 2013–2020. https://doi.org/10.1172/jci82981
Raphemot, Rene, Dora Posfai, and Emily R. Derbyshire. “Current therapies and future possibilities for drug development against liver-stage malaria.The Journal of Clinical Investigation 126, no. 6 (June 2016): 2013–20. https://doi.org/10.1172/jci82981.
Raphemot R, Posfai D, Derbyshire ER. Current therapies and future possibilities for drug development against liver-stage malaria. The Journal of clinical investigation. 2016 Jun;126(6):2013–20.
Raphemot, Rene, et al. “Current therapies and future possibilities for drug development against liver-stage malaria.The Journal of Clinical Investigation, vol. 126, no. 6, June 2016, pp. 2013–20. Epmc, doi:10.1172/jci82981.
Raphemot R, Posfai D, Derbyshire ER. Current therapies and future possibilities for drug development against liver-stage malaria. The Journal of clinical investigation. 2016 Jun;126(6):2013–2020.

Published In

The Journal of clinical investigation

DOI

EISSN

1558-8238

ISSN

0021-9738

Publication Date

June 2016

Volume

126

Issue

6

Start / End Page

2013 / 2020

Related Subject Headings

  • Plasmodium
  • Models, Biological
  • Malaria
  • Liver
  • Immunology
  • Humans
  • Drug Resistance
  • Drug Discovery
  • Drug Design
  • Antimalarials