Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia.
Journal Article (Journal Article)
Patients with common variable immunodeficiency (CVID) have a higher incidence of autoimmune disease, which may mark the disease onset; however, anemia secondary to pure red cell aplasia is an uncommon presenting feature. Here, we describe a case of CVID-like humoral immune deficiency in a child who initially presented with red cell aplasia and ultimately developed progressive bone marrow failure. Although bone marrow transplantation (BMT) has been associated with high mortality in CVID, our patient was successfully treated with a matched sibling BMT and engrafted with >98% donor chimerism and the development of normal antibody titers to diphtheria and tetanus toxoids.
Full Text
Duke Authors
- Buckley, Rebecca Hatcher
- Martin, Paul Langlie
- Mousallem, Talal Imad
- Van Mater, David Sinclaire
- Wang, Endi
Cited Authors
- Sayour, EJ; Mousallem, T; Van Mater, D; Wang, E; Martin, P; Buckley, RH; Barfield, RC
Published Date
- October 2016
Published In
Volume / Issue
- 63 / 10
Start / End Page
- 1856 - 1859
PubMed ID
- 27273469
Pubmed Central ID
- 27273469
Electronic International Standard Serial Number (EISSN)
- 1545-5017
Digital Object Identifier (DOI)
- 10.1002/pbc.26092
Language
- eng
Conference Location
- United States