Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia.

Published

Journal Article

Patients with common variable immunodeficiency (CVID) have a higher incidence of autoimmune disease, which may mark the disease onset; however, anemia secondary to pure red cell aplasia is an uncommon presenting feature. Here, we describe a case of CVID-like humoral immune deficiency in a child who initially presented with red cell aplasia and ultimately developed progressive bone marrow failure. Although bone marrow transplantation (BMT) has been associated with high mortality in CVID, our patient was successfully treated with a matched sibling BMT and engrafted with >98% donor chimerism and the development of normal antibody titers to diphtheria and tetanus toxoids.

Full Text

Duke Authors

Cited Authors

  • Sayour, EJ; Mousallem, T; Van Mater, D; Wang, E; Martin, P; Buckley, RH; Barfield, RC

Published Date

  • October 2016

Published In

Volume / Issue

  • 63 / 10

Start / End Page

  • 1856 - 1859

PubMed ID

  • 27273469

Pubmed Central ID

  • 27273469

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.26092

Language

  • eng

Conference Location

  • United States