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Pediatric high-grade glioma: biologically and clinically in need of new thinking.

Publication ,  Journal Article
Jones, C; Karajannis, MA; Jones, DTW; Kieran, MW; Monje, M; Baker, SJ; Becher, OJ; Cho, Y-J; Gupta, N; Hawkins, C; Hargrave, D; Haas-Kogan, DA ...
Published in: Neuro-oncology
February 2017

High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed previously unappreciated connections among chromatin regulation, developmental signaling, and tumorigenesis. As we begin to unravel the unique developmental origins and distinct biological drivers of this heterogeneous group of tumors, clinical trials need to keep pace. It is important to avoid therapeutic strategies developed purely using data obtained from studies on adult glioblastoma. This approach has resulted in repetitive trials and ineffective treatments being applied to these children, with limited improvement in clinical outcome. The authors of this perspective, comprising biology and clinical expertise in the disease, recently convened to discuss the most effective ways to translate the emerging molecular insights into patient benefit. This article reviews our current understanding of pediatric high-grade glioma and suggests approaches for innovative clinical management.

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Published In

Neuro-oncology

DOI

EISSN

1523-5866

ISSN

1522-8517

Publication Date

February 2017

Volume

19

Issue

2

Start / End Page

153 / 161

Related Subject Headings

  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Grading
  • Humans
  • Glioma
  • Child
  • Cell Transformation, Neoplastic
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Jones, C., Karajannis, M. A., Jones, D. T. W., Kieran, M. W., Monje, M., Baker, S. J., … Weiss, W. A. (2017). Pediatric high-grade glioma: biologically and clinically in need of new thinking. Neuro-Oncology, 19(2), 153–161. https://doi.org/10.1093/neuonc/now101
Jones, Chris, Matthias A. Karajannis, David T. W. Jones, Mark W. Kieran, Michelle Monje, Suzanne J. Baker, Oren J. Becher, et al. “Pediatric high-grade glioma: biologically and clinically in need of new thinking.Neuro-Oncology 19, no. 2 (February 2017): 153–61. https://doi.org/10.1093/neuonc/now101.
Jones C, Karajannis MA, Jones DTW, Kieran MW, Monje M, Baker SJ, et al. Pediatric high-grade glioma: biologically and clinically in need of new thinking. Neuro-oncology. 2017 Feb;19(2):153–61.
Jones, Chris, et al. “Pediatric high-grade glioma: biologically and clinically in need of new thinking.Neuro-Oncology, vol. 19, no. 2, Feb. 2017, pp. 153–61. Epmc, doi:10.1093/neuonc/now101.
Jones C, Karajannis MA, Jones DTW, Kieran MW, Monje M, Baker SJ, Becher OJ, Cho Y-J, Gupta N, Hawkins C, Hargrave D, Haas-Kogan DA, Jabado N, Li X-N, Mueller S, Nicolaides T, Packer RJ, Persson AI, Phillips JJ, Simonds EF, Stafford JM, Tang Y, Pfister SM, Weiss WA. Pediatric high-grade glioma: biologically and clinically in need of new thinking. Neuro-oncology. 2017 Feb;19(2):153–161.
Journal cover image

Published In

Neuro-oncology

DOI

EISSN

1523-5866

ISSN

1522-8517

Publication Date

February 2017

Volume

19

Issue

2

Start / End Page

153 / 161

Related Subject Headings

  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Grading
  • Humans
  • Glioma
  • Child
  • Cell Transformation, Neoplastic
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis