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Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

Publication ,  Journal Article
Medina, EM; Turner, JJ; Gordân, R; Skotheim, JM; Buchler, NE
Published in: eLife
May 10, 2016

Although cell cycle control is an ancient, conserved, and essential process, some core animal and fungal cell cycle regulators share no more sequence identity than non-homologous proteins. Here, we show that evolution along the fungal lineage was punctuated by the early acquisition and entrainment of the SBF transcription factor through horizontal gene transfer. Cell cycle evolution in the fungal ancestor then proceeded through a hybrid network containing both SBF and its ancestral animal counterpart E2F, which is still maintained in many basal fungi. We hypothesize that a virally-derived SBF may have initially hijacked cell cycle control by activating transcription via the cis-regulatory elements targeted by the ancestral cell cycle regulator E2F, much like extant viral oncogenes. Consistent with this hypothesis, we show that SBF can regulate promoters with E2F binding sites in budding yeast.

Duke Scholars

Published In

eLife

DOI

EISSN

2050-084X

Publication Date

May 10, 2016

Volume

5

Issue

MAY2016

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 0601 Biochemistry and Cell Biology
 

Citation

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MLA
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Medina, E. M., Turner, J. J., Gordân, R., Skotheim, J. M., & Buchler, N. E. (2016). Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi. ELife, 5(MAY2016). https://doi.org/10.7554/eLife.09492.001
Medina, E. M., J. J. Turner, R. Gordân, J. M. Skotheim, and N. E. Buchler. “Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi.” ELife 5, no. MAY2016 (May 10, 2016). https://doi.org/10.7554/eLife.09492.001.
Medina EM, Turner JJ, Gordân R, Skotheim JM, Buchler NE. Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi. eLife. 2016 May 10;5(MAY2016).
Medina, E. M., et al. “Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi.” ELife, vol. 5, no. MAY2016, May 2016. Scopus, doi:10.7554/eLife.09492.001.
Medina EM, Turner JJ, Gordân R, Skotheim JM, Buchler NE. Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi. eLife. 2016 May 10;5(MAY2016).

Published In

eLife

DOI

EISSN

2050-084X

Publication Date

May 10, 2016

Volume

5

Issue

MAY2016

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 0601 Biochemistry and Cell Biology