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Simultaneous optical and electrical in vivo analysis of the enteric nervous system.

Publication ,  Journal Article
Rakhilin, N; Barth, B; Choi, J; Muñoz, NL; Kulkarni, S; Jones, JS; Small, DM; Cheng, Y-T; Cao, Y; LaVinka, C; Kan, E; Dong, X; Spencer, M ...
Published in: Nat Commun
June 7, 2016

The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

June 7, 2016

Volume

7

Start / End Page

11800

Location

England

Related Subject Headings

  • Optical Phenomena
  • Microscopy, Fluorescence, Multiphoton
  • Mice
  • Imaging, Three-Dimensional
  • Graphite
  • Fluorescence
  • Enteric Nervous System
  • Electrophysiological Phenomena
  • Electrodes
  • Animals
 

Citation

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Rakhilin, N., Barth, B., Choi, J., Muñoz, N. L., Kulkarni, S., Jones, J. S., … Shen, X. (2016). Simultaneous optical and electrical in vivo analysis of the enteric nervous system. Nat Commun, 7, 11800. https://doi.org/10.1038/ncomms11800
Rakhilin, Nikolai, Bradley Barth, Jiahn Choi, Nini L. Muñoz, Subhash Kulkarni, Jason S. Jones, David M. Small, et al. “Simultaneous optical and electrical in vivo analysis of the enteric nervous system.Nat Commun 7 (June 7, 2016): 11800. https://doi.org/10.1038/ncomms11800.
Rakhilin N, Barth B, Choi J, Muñoz NL, Kulkarni S, Jones JS, et al. Simultaneous optical and electrical in vivo analysis of the enteric nervous system. Nat Commun. 2016 Jun 7;7:11800.
Rakhilin, Nikolai, et al. “Simultaneous optical and electrical in vivo analysis of the enteric nervous system.Nat Commun, vol. 7, June 2016, p. 11800. Pubmed, doi:10.1038/ncomms11800.
Rakhilin N, Barth B, Choi J, Muñoz NL, Kulkarni S, Jones JS, Small DM, Cheng Y-T, Cao Y, LaVinka C, Kan E, Dong X, Spencer M, Pasricha P, Nishimura N, Shen X. Simultaneous optical and electrical in vivo analysis of the enteric nervous system. Nat Commun. 2016 Jun 7;7:11800.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

June 7, 2016

Volume

7

Start / End Page

11800

Location

England

Related Subject Headings

  • Optical Phenomena
  • Microscopy, Fluorescence, Multiphoton
  • Mice
  • Imaging, Three-Dimensional
  • Graphite
  • Fluorescence
  • Enteric Nervous System
  • Electrophysiological Phenomena
  • Electrodes
  • Animals