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Understanding cognition in older patients with cancer.

Publication ,  Journal Article
Karuturi, M; Wong, ML; Hsu, T; Kimmick, GG; Lichtman, SM; Holmes, HM; Inouye, SK; Dale, W; Loh, KP; Whitehead, MI; Magnuson, A; Hurria, A ...
Published in: J Geriatr Oncol
July 2016

Cancer and neurocognitive disorders, such as dementia and delirium, are common and serious diseases in the elderly that are accompanied by high degree of morbidity and mortality. Furthermore, evidence supports the under-diagnosis of both dementia and delirium in older adults. Complex questions exist regarding the interaction of dementia and delirium with cancer, beginning with guidelines on how best measure disease severity, the optimal screening test for either disorder, the appropriate level of intervention in the setting of abnormal findings, and strategies aimed at preventing the development or progression of either process. Ethical concerns emerge in the research setting, pertaining to the detection of cognitive dysfunction in participants, validity of consent, disclosure of abnormal results if screening is pursued, and recommended level of intervention by investigators. Furthermore, understanding the ways in which comorbid cognitive dysfunction and cancer impact both cancer and non-cancer-related outcomes is essential in guiding treatment decisions. In the following article, we will discuss what is presently known of the interactions of pre-existing cognitive impairment and delirium with cancer. We will also discuss identified deficits in our knowledge base, and propose ways in which innovative research may address these gaps.

Duke Scholars

Published In

J Geriatr Oncol

DOI

EISSN

1879-4076

Publication Date

July 2016

Volume

7

Issue

4

Start / End Page

258 / 269

Location

Netherlands

Related Subject Headings

  • Severity of Illness Index
  • Prevalence
  • Neoplasms
  • Mental Status and Dementia Tests
  • Medical Oncology
  • Male
  • Informed Consent
  • Humans
  • Female
  • Dementia
 

Citation

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Chicago
ICMJE
MLA
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Karuturi, M., Wong, M. L., Hsu, T., Kimmick, G. G., Lichtman, S. M., Holmes, H. M., … Mohile, S. (2016). Understanding cognition in older patients with cancer. J Geriatr Oncol, 7(4), 258–269. https://doi.org/10.1016/j.jgo.2016.04.004
Karuturi, Meghan, Melisa L. Wong, Tina Hsu, Gretchen G. Kimmick, Stuart M. Lichtman, Holly M. Holmes, Sharon K. Inouye, et al. “Understanding cognition in older patients with cancer.J Geriatr Oncol 7, no. 4 (July 2016): 258–69. https://doi.org/10.1016/j.jgo.2016.04.004.
Karuturi M, Wong ML, Hsu T, Kimmick GG, Lichtman SM, Holmes HM, et al. Understanding cognition in older patients with cancer. J Geriatr Oncol. 2016 Jul;7(4):258–69.
Karuturi, Meghan, et al. “Understanding cognition in older patients with cancer.J Geriatr Oncol, vol. 7, no. 4, July 2016, pp. 258–69. Pubmed, doi:10.1016/j.jgo.2016.04.004.
Karuturi M, Wong ML, Hsu T, Kimmick GG, Lichtman SM, Holmes HM, Inouye SK, Dale W, Loh KP, Whitehead MI, Magnuson A, Hurria A, Janelsins MC, Mohile S. Understanding cognition in older patients with cancer. J Geriatr Oncol. 2016 Jul;7(4):258–269.
Journal cover image

Published In

J Geriatr Oncol

DOI

EISSN

1879-4076

Publication Date

July 2016

Volume

7

Issue

4

Start / End Page

258 / 269

Location

Netherlands

Related Subject Headings

  • Severity of Illness Index
  • Prevalence
  • Neoplasms
  • Mental Status and Dementia Tests
  • Medical Oncology
  • Male
  • Informed Consent
  • Humans
  • Female
  • Dementia