Joint Effect of Early Microvascular Damage in the Eye &Kidney on Risk of Cardiovascular Events.

Published online

Journal Article

Microalbuminuria is associated with an increased risk of cardiovascular disease (CVD), but not all individuals require treatment. Retinal microvascular abnormalities and microalbuminuria reflect early systemic microvascular changes. We examined the joint effect of retinal abnormalities and microalbuminuria on CVD risk in an Asian cohort. We conducted a prospective, population-based study. Retinal abnormalities were defined as presence of retinopathy and/or retinal venular widening. Microalbuminuria was defined as urinary albumin: creatinine ratio between 30-300 mg/g. Incident CVD was defined as newly diagnosed clinical stroke, acute myocardial infarction or CVD death. Cox regression models were performed to determine the associations between retinal abnormalities and microalbuminuria with risk of CVD, while controlling for established risk factors. 3,496 participants (aged ≥ 40) were free of prevalent CVD. During the follow-up (5.8 years), 126 (3.60%) participants developed CVD. Persons presenting with both retinal abnormalities and microalbuminuria were 6.71 times (95% CI, 2.68, 16.79) as likely to have incident CVD compared with those without either abnormalities. There was a significant interaction effect between retinal abnormalities and microalbuminuria on incident CVD. Assessment of retinal abnormalities in patients with microalbuminuria may provide additional value in identifying persons at risk of developing CVD.

Full Text

Duke Authors

Cited Authors

  • Yip, W; Sabanayagam, C; Ong, PG; Patel, UD; Chow, KY; Tai, ES; Ling, LH; Wong, TY; Cheung, CY-L

Published Date

  • June 8, 2016

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 27442 -

PubMed ID

  • 27273133

Pubmed Central ID

  • 27273133

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep27442

Language

  • eng

Conference Location

  • England