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Innate immune evasion strategies of DNA and RNA viruses.

Publication ,  Journal Article
Beachboard, DC; Horner, SM
Published in: Curr Opin Microbiol
August 2016

Upon infection, both DNA and RNA viruses can be sensed by pattern recognition receptors (PRRs) in the cytoplasm or the nucleus to activate antiviral innate immunity. Sensing of viral products leads to the activation of a signaling cascade that ultimately results in transcriptional activation of type I and III interferons, as well as other antiviral genes that together mediate viral clearance and inhibit viral spread. Therefore, in order for viruses to replicate and spread efficiently, they must inhibit the host signaling pathways that induce the innate antiviral immune response. In this review, we will highlight recent advances in the understanding of the mechanisms by which viruses evade PRR detection, intermediate signaling molecule activation, transcription factor activation, and the actions of antiviral proteins.

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Published In

Curr Opin Microbiol

DOI

EISSN

1879-0364

Publication Date

August 2016

Volume

32

Start / End Page

113 / 119

Location

England

Related Subject Headings

  • Signal Transduction
  • Receptors, Pattern Recognition
  • Receptors, Immunologic
  • RNA Viruses
  • Microbiology
  • Interferon Type I
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Host-Pathogen Interactions
 

Citation

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Beachboard, D. C., & Horner, S. M. (2016). Innate immune evasion strategies of DNA and RNA viruses. Curr Opin Microbiol, 32, 113–119. https://doi.org/10.1016/j.mib.2016.05.015
Beachboard, Dia C., and Stacy M. Horner. “Innate immune evasion strategies of DNA and RNA viruses.Curr Opin Microbiol 32 (August 2016): 113–19. https://doi.org/10.1016/j.mib.2016.05.015.
Beachboard DC, Horner SM. Innate immune evasion strategies of DNA and RNA viruses. Curr Opin Microbiol. 2016 Aug;32:113–9.
Beachboard, Dia C., and Stacy M. Horner. “Innate immune evasion strategies of DNA and RNA viruses.Curr Opin Microbiol, vol. 32, Aug. 2016, pp. 113–19. Pubmed, doi:10.1016/j.mib.2016.05.015.
Beachboard DC, Horner SM. Innate immune evasion strategies of DNA and RNA viruses. Curr Opin Microbiol. 2016 Aug;32:113–119.
Journal cover image

Published In

Curr Opin Microbiol

DOI

EISSN

1879-0364

Publication Date

August 2016

Volume

32

Start / End Page

113 / 119

Location

England

Related Subject Headings

  • Signal Transduction
  • Receptors, Pattern Recognition
  • Receptors, Immunologic
  • RNA Viruses
  • Microbiology
  • Interferon Type I
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Host-Pathogen Interactions