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Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes.

Publication ,  Journal Article
Wu, RR; Myers, RA; Hauser, ER; Vorderstrasse, A; Cho, A; Ginsburg, GS; Orlando, LA
Published in: J Genet Couns
February 2017

Family health history (FHH) in the context of risk assessment has been shown to positively impact risk perception and behavior change. The added value of genetic risk testing is less certain. The aim of this study was to determine the impact of Type 2 Diabetes (T2D) FHH and genetic risk counseling on behavior and its cognitive precursors. Subjects were non-diabetic patients randomized to counseling that included FHH +/- T2D genetic testing. Measurements included weight, BMI, fasting glucose at baseline and 12 months and behavioral and cognitive precursor (T2D risk perception and control over disease development) surveys at baseline, 3, and 12 months. 391 subjects enrolled of which 312 completed the study. Behavioral and clinical outcomes did not differ across FHH or genetic risk but cognitive precursors did. Higher FHH risk was associated with a stronger perceived T2D risk (pKendall < 0.001) and with a perception of "serious" risk (pKendall < 0.001). Genetic risk did not influence risk perception, but was correlated with an increase in perception of "serious" risk for moderate (pKendall = 0.04) and average FHH risk subjects (pKendall = 0.01), though not for the high FHH risk group. Perceived control over T2D risk was high and not affected by FHH or genetic risk. FHH appears to have a strong impact on cognitive precursors of behavior change, suggesting it could be leveraged to enhance risk counseling, particularly when lifestyle change is desirable. Genetic risk was able to alter perceptions about the seriousness of T2D risk in those with moderate and average FHH risk, suggesting that FHH could be used to selectively identify individuals who may benefit from genetic risk testing.

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Published In

J Genet Couns

DOI

EISSN

1573-3599

Publication Date

February 2017

Volume

26

Issue

1

Start / End Page

133 / 140

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Primary Prevention
  • Middle Aged
  • Medical History Taking
  • Male
  • Life Style
  • Humans
  • Health Behavior
  • Genetics & Heredity
  • Genetic Testing
 

Citation

APA
Chicago
ICMJE
MLA
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Wu, R. R., Myers, R. A., Hauser, E. R., Vorderstrasse, A., Cho, A., Ginsburg, G. S., & Orlando, L. A. (2017). Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes. J Genet Couns, 26(1), 133–140. https://doi.org/10.1007/s10897-016-9988-z
Wu, R Ryanne, Rachel A. Myers, Elizabeth R. Hauser, Allison Vorderstrasse, Alex Cho, Geoffrey S. Ginsburg, and Lori A. Orlando. “Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes.J Genet Couns 26, no. 1 (February 2017): 133–40. https://doi.org/10.1007/s10897-016-9988-z.
Wu RR, Myers RA, Hauser ER, Vorderstrasse A, Cho A, Ginsburg GS, et al. Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes. J Genet Couns. 2017 Feb;26(1):133–40.
Wu, R. Ryanne, et al. “Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes.J Genet Couns, vol. 26, no. 1, Feb. 2017, pp. 133–40. Pubmed, doi:10.1007/s10897-016-9988-z.
Wu RR, Myers RA, Hauser ER, Vorderstrasse A, Cho A, Ginsburg GS, Orlando LA. Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes. J Genet Couns. 2017 Feb;26(1):133–140.
Journal cover image

Published In

J Genet Couns

DOI

EISSN

1573-3599

Publication Date

February 2017

Volume

26

Issue

1

Start / End Page

133 / 140

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Primary Prevention
  • Middle Aged
  • Medical History Taking
  • Male
  • Life Style
  • Humans
  • Health Behavior
  • Genetics & Heredity
  • Genetic Testing