Integrated and real-time quantitative analysis using cyberphysical digital-microfluidic biochips

Conference Paper

© 2016 EDAA. Considerable effort has recently been directed towards the implementation of molecular bioassays on digital-microfluidic biochips. However, today's solutions suffer from the drawback that multiple sample pathways are not supported and on-chip reconfigurable devices are not efficiently exploited. To overcome this problem, we present a spatial-reconfiguration technique that incorporates resource-sharing specifications into the synthesis flow. This technique is combined with cyberphysical integration to develop the first design-automation framework for quantitative gene expression. The proposed framework is based on a real-time resource-allocation algorithm that responds promptly to decisions about the protocol flow received from a firmware layer. Simulation results show that our adaptive framework efficiently utilizes on-chip resources to reduce time-to-result without sacrificing the chip's lifetime.

Duke Authors

Cited Authors

  • Ibrahim, M; Chakrabarty, K; Scott, K

Published Date

  • April 25, 2016

Published In

  • Proceedings of the 2016 Design, Automation and Test in Europe Conference and Exhibition, DATE 2016

Start / End Page

  • 630 - 635

International Standard Book Number 13 (ISBN-13)

  • 9783981537062

Citation Source

  • Scopus