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Associations between smoking behavior-related alleles and the risk of melanoma.

Publication ,  Journal Article
Wu, W; Liu, H; Song, F; Chen, L-S; Kraft, P; Wei, Q; Han, J
Published in: Oncotarget
July 26, 2016

Several studies have reported that cigarette smoking is inversely associated with the risk of melanoma. This study further tested whether incorporating genetic factors will provide another level of evaluation of mechanisms underlying the association between smoking and risk of melanoma. We investigated the association between SNPs selected from genome-wide association studies (GWAS) on smoking behaviors and risk of melanoma using 2,298 melanoma cases and 6,654 controls. Among 16 SNPs, three (rs16969968 [A], rs1051730 [A] and rs2036534 [C] in the 15q25.1 region) reached significance for association with melanoma risk in men (0.01 < = P values < = 0.02; 0.85 < = Odds Ratios (ORs) <= 1.20). There was association between the genetic scores based on the number of smoking behavior-risk alleles and melanoma risk with P-trend = 0.005 among HPFS. Further association with smoking behaviors indicating those three SNPs (rs16969968 [A], rs1051730 [A] and rs2036534 [C]) significantly associated with number of cigarettes smoked per day, CPD, with P = 0.009, 0.011 and 0.001 respectively. The SNPs rs215605 in the PDE1C gene and rs6265 in the BDNF gene significantly interacted with smoking status on melanoma risk (interaction P = 0.005 and P = 0.003 respectively). Our study suggests that smoking behavior-related SNPs are likely to play a role in melanoma development and the potential public health importance of polymorphisms in the CHRNA5-A3-B4 gene cluster. Further larger studies are warranted to validate the findings.

Duke Scholars

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Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

July 26, 2016

Volume

7

Issue

30

Start / End Page

47366 / 47375

Location

United States

Related Subject Headings

  • Smoking
  • Risk
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Melanoma
  • Male
  • Humans
  • Genome-Wide Association Study
  • Female
  • Cyclic Nucleotide Phosphodiesterases, Type 1
 

Citation

APA
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Wu, W., Liu, H., Song, F., Chen, L.-S., Kraft, P., Wei, Q., & Han, J. (2016). Associations between smoking behavior-related alleles and the risk of melanoma. Oncotarget, 7(30), 47366–47375. https://doi.org/10.18632/oncotarget.10144
Wu, Wenting, Hongliang Liu, Fengju Song, Li-Shiun Chen, Peter Kraft, Qingyi Wei, and Jiali Han. “Associations between smoking behavior-related alleles and the risk of melanoma.Oncotarget 7, no. 30 (July 26, 2016): 47366–75. https://doi.org/10.18632/oncotarget.10144.
Wu W, Liu H, Song F, Chen L-S, Kraft P, Wei Q, et al. Associations between smoking behavior-related alleles and the risk of melanoma. Oncotarget. 2016 Jul 26;7(30):47366–75.
Wu, Wenting, et al. “Associations between smoking behavior-related alleles and the risk of melanoma.Oncotarget, vol. 7, no. 30, July 2016, pp. 47366–75. Pubmed, doi:10.18632/oncotarget.10144.
Wu W, Liu H, Song F, Chen L-S, Kraft P, Wei Q, Han J. Associations between smoking behavior-related alleles and the risk of melanoma. Oncotarget. 2016 Jul 26;7(30):47366–47375.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

July 26, 2016

Volume

7

Issue

30

Start / End Page

47366 / 47375

Location

United States

Related Subject Headings

  • Smoking
  • Risk
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Melanoma
  • Male
  • Humans
  • Genome-Wide Association Study
  • Female
  • Cyclic Nucleotide Phosphodiesterases, Type 1