Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status.

Published

Journal Article

The thymus is critical for mounting an effective immune response and maintaining health. However, epidemiologic studies characterizing thymic function in the population setting are lacking. Using data from 263 adults in the Detroit Neighborhood Health Study, we examined thymic function as measured by the number of signal joint T-cell receptor excision circles (sjTREC) and assessed associations with established indicators of physiological health. Overall, increasing age and male gender were significantly associated with reduced thymic function. Adjusting for covariates, individuals with elevated levels of the pro-inflammatory biomarkers C-reactive protein (β: -0.50 [95% CI: -0.82, -0.18] for moderate elevation, β: -0.29 [95% CI: -0.59, 0.00] for high elevation) and interleukin-6 (β: -0.60 [95% CI: -0.92, -0.28] for moderate elevation, β: -0.43 [95% CI: -0.77, -0.08] for severe elevation) also had lower thymic function. Compared to individuals with a BMI < 25, individuals who were overweight (β: 0.36 [95% CI: 0.07, 0.64]) or obese (β: 0.27 [95% CI: -0.03, 0.56]) had higher thymic function. Differences by self-rated health were not statistically significant. Our findings underscore demographic- and health-related gradients in thymic function among adult residents of Detroit, suggesting thymic function may be an important biomarker of health status in adults at the population level.

Full Text

Duke Authors

Cited Authors

  • Feinstein, L; Ferrando-Martínez, S; Leal, M; Zhou, X; Sempowski, GD; Wildman, DE; Uddin, M; Aiello, AE

Published Date

  • 2016

Published In

Volume / Issue

  • 62 / 2

Start / End Page

  • 208 - 221

PubMed ID

  • 27337555

Pubmed Central ID

  • 27337555

Electronic International Standard Serial Number (EISSN)

  • 1948-5573

Digital Object Identifier (DOI)

  • 10.1080/19485565.2016.1172199

Language

  • eng

Conference Location

  • United States