Advancing cardiovascular tissue engineering.


Journal Article (Review)

Cardiovascular tissue engineering offers the promise of biologically based repair of injured and damaged blood vessels, valves, and cardiac tissue. Major advances in cardiovascular tissue engineering over the past few years involve improved methods to promote the establishment and differentiation of induced pluripotent stem cells (iPSCs), scaffolds from decellularized tissue that may produce more highly differentiated tissues and advance clinical translation, improved methods to promote vascularization, and novel in vitro microphysiological systems to model normal and diseased tissue function. iPSC technology holds great promise, but robust methods are needed to further promote differentiation. Differentiation can be further enhanced with chemical, electrical, or mechanical stimuli.

Full Text

Duke Authors

Cited Authors

  • Truskey, GA

Published Date

  • January 2016

Published In

Volume / Issue

  • 5 /

PubMed ID

  • 27303643

Pubmed Central ID

  • 27303643

Electronic International Standard Serial Number (EISSN)

  • 2046-1402

International Standard Serial Number (ISSN)

  • 2046-1402

Digital Object Identifier (DOI)

  • 10.12688/f1000research.8237.1


  • eng