Serum antibodies to huntingtin interacting protein-1: a new blood test for prostate cancer.

Published

Journal Article

Huntingtin-interacting protein 1 (HIP1) is frequently overexpressed in prostate cancer. HIP1 is a clathrin-binding protein involved in growth factor receptor trafficking that transforms fibroblasts by prolonging the half-life of growth factor receptors. In addition to human cancers, HIP1 is also overexpressed in prostate tumors from the transgenic adenocarcinoma of the mouse prostate (TRAMP) mouse model. Here we provide evidence that HIP1 plays an important role in mouse tumor development, as tumor formation in the TRAMP mice was impaired in the Hip1null/null background. In addition, we report that autoantibodies to HIP1 developed in the sera of TRAMP mice with prostate cancer as well as in the sera from human prostate cancer patients. This led to the development of an anti-HIP1 serum test in humans that had a similar sensitivity and specificity to the anti-alpha-methylacyl CoA racemase (AMACR) and prostate-specific antigen tests for prostate cancer and when combined with the anti-AMACR test yielded a specificity of 97%. These data suggest that HIP1 plays a functional role in tumorigenesis and that a positive HIP1 autoantibody test may be an important serum marker of prostate cancer.

Full Text

Duke Authors

Cited Authors

  • Bradley, SV; Oravecz-Wilson, KI; Bougeard, G; Mizukami, I; Li, L; Munaco, AJ; Sreekumar, A; Corradetti, MN; Chinnaiyan, AM; Sanda, MG; Ross, TS

Published Date

  • May 2005

Published In

Volume / Issue

  • 65 / 10

Start / End Page

  • 4126 - 4133

PubMed ID

  • 15899803

Pubmed Central ID

  • 15899803

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

International Standard Serial Number (ISSN)

  • 0008-5472

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.can-04-4658

Language

  • eng