Oxidative stress in diseases of the human cornea.

Journal Article (Journal Article;Review)

Intense exposure to light, robust metabolic activity, and high oxygen tension render the human eye particularly vulnerable to oxidative damage and the list of ophthalmological disorders implicating reactive oxygen and nitrogen species is rapidly expanding. Here, we review the roles of oxidative stress in the etiopathogeneses and pathophysiology of diseases of the human cornea including pterygium, keratoconus, trauma and chemical injury, and a host of inflammatory, metabolic, degenerative, and iatrogenic conditions. Data from animal and tissue culture experimentation germane to these conditions are also adduced.

Full Text

Duke Authors

Cited Authors

  • Shoham, A; Hadziahmetovic, M; Dunaief, JL; Mydlarski, MB; Schipper, HM

Published Date

  • October 15, 2008

Published In

Volume / Issue

  • 45 / 8

Start / End Page

  • 1047 - 1055

PubMed ID

  • 18718524

International Standard Serial Number (ISSN)

  • 0891-5849

Digital Object Identifier (DOI)

  • 10.1016/j.freeradbiomed.2008.07.021


  • eng

Conference Location

  • United States