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The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.

Publication ,  Journal Article
Hadziahmetovic, M; Pajic, M; Grieco, S; Song, Y; Song, D; Li, Y; Cwanger, A; Iacovelli, J; Chu, S; Ying, G-S; Connelly, J; Spino, M; Dunaief, JL
Published in: Transl Vis Sci Technol
2012

PURPOSE: To investigate the effect of the iron chelator deferiprone (DFP) on sodium iodate (NaIO3)-induced retinal degeneration and on the hereditary retinal degeneration caused by the rd6 mutation. METHODS: Retinas from NaIO3-treated C57BL/6J mice, with or without DFP cotreatment, were analyzed by histology, immunofluorescence, and quantitative PCR to investigate the effect of DFP on retinal degeneration. To facilitate photoreceptor quantification, we developed a new function of MATLAB to perform this task in a semiautomated fashion. Additionally, rd6 mice treated with or without DFP were analyzed by histology to assess possible protection. RESULTS: In NaIO3-treated mice, DFP protected against retinal degeneration and significantly decreased expression of the oxidative stress-related gene heme oxygenase-1 and the complement gene C3. DFP treatment partially protected against NaIO3-induced reduction in the levels of mRNAs encoded by visual cycle genes rhodopsin (Rho) and retinal pigment epithelium-specific 65 kDa protein (Rpe65), consistent with the morphological data indicating preservation of photoreceptors and RPE, respectively. DFP treatment also protected photoreceptors in rd6 mice. CONCLUSIONS: The oral iron chelator DFP provides significant protection against retinal degeneration induced through different modalities. This suggests that iron chelation could be useful as a treatment for retinal degeneration even when the main etiology does not appear to be iron dysregulation. TRANSLATIONAL RELEVANCE: These data provide proof of principle that the oral iron chelator DFP can protect the retina against diverse insults. Further testing of DFP in additional animal retinal degeneration models at a range of doses is warranted.

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Published In

Transl Vis Sci Technol

DOI

ISSN

2164-2591

Publication Date

2012

Volume

1

Issue

2

Start / End Page

7

Location

United States

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
  • 0903 Biomedical Engineering
 

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Hadziahmetovic, M., Pajic, M., Grieco, S., Song, Y., Song, D., Li, Y., … Dunaief, J. L. (2012). The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms. Transl Vis Sci Technol, 1(2), 7. https://doi.org/10.1167/tvst.1.2.7
Hadziahmetovic, Majda, Miroslav Pajic, Steven Grieco, Ying Song, Delu Song, Yafeng Li, Alyssa Cwanger, et al. “The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.Transl Vis Sci Technol 1, no. 2 (2012): 7. https://doi.org/10.1167/tvst.1.2.7.
Hadziahmetovic M, Pajic M, Grieco S, Song Y, Song D, Li Y, et al. The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms. Transl Vis Sci Technol. 2012;1(2):7.
Hadziahmetovic, Majda, et al. “The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.Transl Vis Sci Technol, vol. 1, no. 2, 2012, p. 7. Pubmed, doi:10.1167/tvst.1.2.7.
Hadziahmetovic M, Pajic M, Grieco S, Song Y, Song D, Li Y, Cwanger A, Iacovelli J, Chu S, Ying G-S, Connelly J, Spino M, Dunaief JL. The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms. Transl Vis Sci Technol. 2012;1(2):7.

Published In

Transl Vis Sci Technol

DOI

ISSN

2164-2591

Publication Date

2012

Volume

1

Issue

2

Start / End Page

7

Location

United States

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
  • 0903 Biomedical Engineering