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Glucagon or insulin suppressed biliary lipid excretion in dog and man.

Publication ,  Journal Article
Meyers, WC; Jones, RS
Published in: Ann Surg
December 1979

The possibility that gastrointestinal hormones influence biliary lipid secretion was studied further in chronic bile fistula dogs and subsequently in a patient with a balloon-occludable t-tube. After stabilization of bile flow in the dog by infusing 500 mg/hr sodium taurocholate, glucagon and insulin increased bile flow, decreased cholesterol output, and had no effect on phospholipid or bile salt output. Similarly, during reinfusion of bile in the human subject, glucagon increased bile flow, decreased cholesterol output and had no effect on bile salt output. Phospholipid secretion decreased, as had occurred at a lower bile salt infusion rate in the chronic bile fistula dog. These findings suggest that glucagon or insulin may play a role in regulating cholesterol secretion in dog and man, and that mechanisms other than simple dilution of micelles are operative.

Duke Scholars

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

December 1979

Volume

190

Issue

6

Start / End Page

709 / 718

Location

United States

Related Subject Headings

  • Taurocholic Acid
  • Surgery
  • Phospholipids
  • Insulin
  • Humans
  • Glucagon
  • Fistula
  • Dogs
  • Chronic Disease
  • Cholesterol
 

Citation

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Meyers, W. C., & Jones, R. S. (1979). Glucagon or insulin suppressed biliary lipid excretion in dog and man. Ann Surg, 190(6), 709–718. https://doi.org/10.1097/00000658-197912000-00007
Meyers, W. C., and R. S. Jones. “Glucagon or insulin suppressed biliary lipid excretion in dog and man.Ann Surg 190, no. 6 (December 1979): 709–18. https://doi.org/10.1097/00000658-197912000-00007.
Meyers WC, Jones RS. Glucagon or insulin suppressed biliary lipid excretion in dog and man. Ann Surg. 1979 Dec;190(6):709–18.
Meyers, W. C., and R. S. Jones. “Glucagon or insulin suppressed biliary lipid excretion in dog and man.Ann Surg, vol. 190, no. 6, Dec. 1979, pp. 709–18. Pubmed, doi:10.1097/00000658-197912000-00007.
Meyers WC, Jones RS. Glucagon or insulin suppressed biliary lipid excretion in dog and man. Ann Surg. 1979 Dec;190(6):709–718.

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

December 1979

Volume

190

Issue

6

Start / End Page

709 / 718

Location

United States

Related Subject Headings

  • Taurocholic Acid
  • Surgery
  • Phospholipids
  • Insulin
  • Humans
  • Glucagon
  • Fistula
  • Dogs
  • Chronic Disease
  • Cholesterol