Personalized and targeted therapy of esophageal squamous cell carcinoma: an update.
Journal Article (Journal Article;Review)
Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research. In this review, we update recent progress in the research area of targeted therapy for ESCC. SOX2 and its associated proteins (e.g., ΔNP63α), which regulate lineage survival of ESCC cells, are proposed as therapeutic targets. It is believed that targeting the lineage-survival mechanism may be more effective than targeting other mechanisms. With the advent of a new era of personalized targeted therapy, there is a need to move from the tumor-centric model into an organismic model.
Full Text
Duke Authors
Cited Authors
- Liu, Y; Xiong, Z; Beasley, A; D'Amico, T; Chen, XL
Published Date
- October 2016
Published In
Volume / Issue
- 1381 / 1
Start / End Page
- 66 - 73
PubMed ID
- 27399176
Pubmed Central ID
- PMC5083215
Electronic International Standard Serial Number (EISSN)
- 1749-6632
Digital Object Identifier (DOI)
- 10.1111/nyas.13144
Language
- eng
Conference Location
- United States