Personalized and targeted therapy of esophageal squamous cell carcinoma: an update.

Journal Article (Journal Article;Review)

Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research. In this review, we update recent progress in the research area of targeted therapy for ESCC. SOX2 and its associated proteins (e.g., ΔNP63α), which regulate lineage survival of ESCC cells, are proposed as therapeutic targets. It is believed that targeting the lineage-survival mechanism may be more effective than targeting other mechanisms. With the advent of a new era of personalized targeted therapy, there is a need to move from the tumor-centric model into an organismic model.

Full Text

Duke Authors

Cited Authors

  • Liu, Y; Xiong, Z; Beasley, A; D'Amico, T; Chen, XL

Published Date

  • October 2016

Published In

Volume / Issue

  • 1381 / 1

Start / End Page

  • 66 - 73

PubMed ID

  • 27399176

Pubmed Central ID

  • PMC5083215

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1111/nyas.13144


  • eng

Conference Location

  • United States