Embracing rejection: Immunologic trends in brain metastasis.

Journal Article (Journal Article;Review)

Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to the blood-brain barrier (BBB), alterations to the brain microenvironment, and mechanisms for escaping CNS immunosurveillance. In the emerging era of immunotherapy, understanding how metastases are influenced by the immunologic peculiarities of the CNS will be crucial to forging therapeutic advances. In this review, the immunology of brain metastasis is explored.

Full Text

Duke Authors

Cited Authors

  • Farber, SH; Tsvankin, V; Narloch, JL; Kim, GJ; Salama, AKS; Vlahovic, G; Blackwell, KL; Kirkpatrick, JP; Fecci, PE

Published Date

  • July 2016

Published In

Volume / Issue

  • 5 / 7

Start / End Page

  • e1172153 -

PubMed ID

  • 27622023

Pubmed Central ID

  • PMC5006920

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.1080/2162402X.2016.1172153


  • eng

Conference Location

  • United States