Embracing rejection: Immunologic trends in brain metastasis.
Journal Article (Journal Article;Review)
Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to the blood-brain barrier (BBB), alterations to the brain microenvironment, and mechanisms for escaping CNS immunosurveillance. In the emerging era of immunotherapy, understanding how metastases are influenced by the immunologic peculiarities of the CNS will be crucial to forging therapeutic advances. In this review, the immunology of brain metastasis is explored.
Full Text
Duke Authors
- Blackwell, Kimberly Lynn
- Fecci, Peter Edward
- Kim, Grace Jewel
- Kirkpatrick, John P.
- Salama, April Kelly Scott
- Vlahovic, Gordana
Cited Authors
- Farber, SH; Tsvankin, V; Narloch, JL; Kim, GJ; Salama, AKS; Vlahovic, G; Blackwell, KL; Kirkpatrick, JP; Fecci, PE
Published Date
- July 2016
Published In
Volume / Issue
- 5 / 7
Start / End Page
- e1172153 -
PubMed ID
- 27622023
Pubmed Central ID
- PMC5006920
International Standard Serial Number (ISSN)
- 2162-4011
Digital Object Identifier (DOI)
- 10.1080/2162402X.2016.1172153
Language
- eng
Conference Location
- United States