Skip to main content
Journal cover image

Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.

Publication ,  Journal Article
Greschner, M; Heitman, AK; Field, GD; Li, PH; Ahn, D; Sher, A; Litke, AM; Chichilnisky, EJ
Published in: Current biology : CB
August 2016

Understanding the function of modulatory interneuron networks is a major challenge, because such networks typically operate over long spatial scales and involve many neurons of different types. Here, we use an indirect electrical imaging method to reveal the function of a spatially extended, recurrent retinal circuit composed of two cell types. This recurrent circuit produces peripheral response suppression of early visual signals in the primate magnocellular visual pathway. We identify a type of polyaxonal amacrine cell physiologically via its distinctive electrical signature, revealed by electrical coupling with ON parasol retinal ganglion cells recorded using a large-scale multi-electrode array. Coupling causes the amacrine cells to fire spikes that propagate radially over long distances, producing GABA-ergic inhibition of other ON parasol cells recorded near the amacrine cell axonal projections. We propose and test a model for the function of this amacrine cell type, in which the extra-classical receptive field of ON parasol cells is formed by reciprocal inhibition from other ON parasol cells in the periphery, via the electrically coupled amacrine cell network.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Current biology : CB

DOI

EISSN

1879-0445

ISSN

0960-9822

Publication Date

August 2016

Volume

26

Issue

15

Start / End Page

1935 / 1942

Related Subject Headings

  • Visual Pathways
  • Retina
  • Macaca mulatta
  • Macaca fascicularis
  • Interneurons
  • Electrophysiological Phenomena
  • Developmental Biology
  • Animals
  • Amacrine Cells
  • 52 Psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Greschner, M., Heitman, A. K., Field, G. D., Li, P. H., Ahn, D., Sher, A., … Chichilnisky, E. J. (2016). Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging. Current Biology : CB, 26(15), 1935–1942. https://doi.org/10.1016/j.cub.2016.05.051
Greschner, Martin, Alexander K. Heitman, Greg D. Field, Peter H. Li, Daniel Ahn, Alexander Sher, Alan M. Litke, and E. J. Chichilnisky. “Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.Current Biology : CB 26, no. 15 (August 2016): 1935–42. https://doi.org/10.1016/j.cub.2016.05.051.
Greschner M, Heitman AK, Field GD, Li PH, Ahn D, Sher A, et al. Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging. Current biology : CB. 2016 Aug;26(15):1935–42.
Greschner, Martin, et al. “Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.Current Biology : CB, vol. 26, no. 15, Aug. 2016, pp. 1935–42. Epmc, doi:10.1016/j.cub.2016.05.051.
Greschner M, Heitman AK, Field GD, Li PH, Ahn D, Sher A, Litke AM, Chichilnisky EJ. Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging. Current biology : CB. 2016 Aug;26(15):1935–1942.
Journal cover image

Published In

Current biology : CB

DOI

EISSN

1879-0445

ISSN

0960-9822

Publication Date

August 2016

Volume

26

Issue

15

Start / End Page

1935 / 1942

Related Subject Headings

  • Visual Pathways
  • Retina
  • Macaca mulatta
  • Macaca fascicularis
  • Interneurons
  • Electrophysiological Phenomena
  • Developmental Biology
  • Animals
  • Amacrine Cells
  • 52 Psychology