Three-dimensional echo-planar cine imaging of cerebral blood supply using arterial spin labeling.

Journal Article (Journal Article)


Echo-planar imaging (EPI) with CYlindrical Center-out spatiaL Encoding (EPICYCLE) is introduced as a novel hybrid three-dimensional (3D) EPI technique. Its suitability for the tracking of a short bolus created by pseudo-continuous arterial spin labeling (pCASL) through the cerebral vasculature is demonstrated.

Materials and methods

EPICYCLE acquires two-dimensional planes of k-space along center-out trajectories. These "spokes" are rotated from shot to shot about a common axis to encode a k-space cylinder. To track a bolus of labeled blood, the same subset of evenly distributed spokes is acquired in a cine fashion after a short period of pCASL. This process is repeated for all subsets to fill the whole 3D k-space of each time frame.


The passage of short pCASL boluses through the vasculature of a 3D imaging slab was successfully imaged using EPICYCLE. By choosing suitable sequence parameters, the impact of slab excitation on the bolus shape could be minimized. Parametric maps of signal amplitude, transit time, and bolus width reflected typical features of blood transport in large vessels.


The EPICYCLE technique was successfully applied to track a short bolus of labeled arterial blood during its passage through the cerebral vasculature.

Full Text

Duke Authors

Cited Authors

  • Shrestha, M; Mildner, T; Schlumm, T; Robertson, SH; Möller, H

Published Date

  • December 2016

Published In

Volume / Issue

  • 29 / 6

Start / End Page

  • 799 - 810

PubMed ID

  • 27225871

Pubmed Central ID

  • PMC5124058

Electronic International Standard Serial Number (EISSN)

  • 1352-8661

International Standard Serial Number (ISSN)

  • 0968-5243

Digital Object Identifier (DOI)

  • 10.1007/s10334-016-0565-0


  • eng