Security Assessment of Cyberphysical Digital Microfluidic Biochips.

Journal Article (Journal Article)

A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we provide the first assessment of the security vulnerabilities of DMFBs. We identify result-manipulation attacks on a DMFB that maliciously alter the assay outcomes. Two practical result-manipulation attacks are shown on a DMFB platform performing enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the attacker tampers with the calibration curve of the assay operation. We then identify denial-of-service attacks, where the attacker can disrupt the assay operation by tampering either with the droplet-routing algorithm or with the actuation sequence. We demonstrate these attacks using a digital microfluidic synthesis simulator. The results show that the attacks are easy to implement and hard to detect. Therefore, this work highlights the need for effective protections against malicious modifications in DMFBs.

Full Text

Duke Authors

Cited Authors

  • Ali, SS; Ibrahim, M; Sinanoglu, O; Chakrabarty, K; Karri, R

Published Date

  • May 2016

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 445 - 458

PubMed ID

  • 26701892

Pubmed Central ID

  • 26701892

Electronic International Standard Serial Number (EISSN)

  • 1557-9964

International Standard Serial Number (ISSN)

  • 1545-5963

Digital Object Identifier (DOI)

  • 10.1109/tcbb.2015.2509991


  • eng