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Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy.

Publication ,  Journal Article
Calenda, BW; Fuster, V; Halperin, JL; Granger, CB
Published in: Nat Rev Cardiol
September 2016

Atrial fibrillation (AF) is a complex phenomenon associated with electrical, mechanical, and structural abnormalities of the atria. Ischaemic stroke in AF is only partially understood, but the mechanisms are known to be related to the atrial substrate as well as the atrial rhythm. The temporal dissociation between timing of AF and occurrence of stroke has led to the hypothesis that fibrotic, prothrombotic atrial tissue is an important cause of thrombus formation in patients with AF, independent of the atrial rhythm. Current stroke risk scores are practical, but limited in their capacity to predict stroke risk accurately in individual patients. Stroke prediction might be improved by the addition of emerging risk factors, many of which are expressions of atrial fibrosis. The use of novel parameters, including clinical criteria, biomarkers, and imaging data, might improve stroke risk prediction and inform on optimal treatment for patients with AF and perhaps individuals only at risk of AF.

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Published In

Nat Rev Cardiol

DOI

EISSN

1759-5010

Publication Date

September 2016

Volume

13

Issue

9

Start / End Page

549 / 559

Location

England

Related Subject Headings

  • Stroke
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Predictive Value of Tests
  • Humans
  • Heart Atria
  • Fibrosis
  • Decision Support Techniques
  • Clinical Decision-Making
 

Citation

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Calenda, B. W., Fuster, V., Halperin, J. L., & Granger, C. B. (2016). Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy. Nat Rev Cardiol, 13(9), 549–559. https://doi.org/10.1038/nrcardio.2016.106
Calenda, Brandon W., Valentin Fuster, Jonathan L. Halperin, and Christopher B. Granger. “Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy.Nat Rev Cardiol 13, no. 9 (September 2016): 549–59. https://doi.org/10.1038/nrcardio.2016.106.
Calenda BW, Fuster V, Halperin JL, Granger CB. Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy. Nat Rev Cardiol. 2016 Sep;13(9):549–59.
Calenda, Brandon W., et al. “Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy.Nat Rev Cardiol, vol. 13, no. 9, Sept. 2016, pp. 549–59. Pubmed, doi:10.1038/nrcardio.2016.106.
Calenda BW, Fuster V, Halperin JL, Granger CB. Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy. Nat Rev Cardiol. 2016 Sep;13(9):549–559.

Published In

Nat Rev Cardiol

DOI

EISSN

1759-5010

Publication Date

September 2016

Volume

13

Issue

9

Start / End Page

549 / 559

Location

England

Related Subject Headings

  • Stroke
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Predictive Value of Tests
  • Humans
  • Heart Atria
  • Fibrosis
  • Decision Support Techniques
  • Clinical Decision-Making