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Synthesis and secretion of alkaline phosphatase in vitro from first-trimester and term human placentas

Publication ,  Journal Article
Galski, H; Fridovich, SE; Weinstein, D; De Groot, N; Segal, S; Folman, R; Hochberg, AA
Published in: Biochemical Journal
March 15, 1981

The synthesis and secretion of alkaline phosphatases in vitro by human placental tissue incubated in organ culture were studied. First-trimester placenta synthesizes and secretes two different alkaline phosphatase isoenzymes (heat-labile and heat-stable), whereas in term placenta nearly all the alkaline phosphatase synthesized and secreted is heat-stable. The specific activities of alkaline phosphatases in first-trimester and term placental tissue remain constant throughout the time course of incubation. In the media, specific activities increase with time. Hence, alkaline phosphatase synthesis seems to be the driving force for its own secretion. The rates of synthesis de novo and of alkaline phosphatases were measured. The specific radioactivities of the secreted alkaline phosphatases were higher than the corresponding specific radioactivities in the tissue throughout the entire incubation period. The intracellular distribution of the alkaline phosphatase isoenzymes was compared.

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Published In

Biochemical Journal

DOI

ISSN

0264-6021

Publication Date

March 15, 1981

Volume

194

Issue

3

Start / End Page

857 / 866

Publisher

Portland Press Ltd.

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
  • 03 Chemical Sciences
 

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Galski, H., Fridovich, S. E., Weinstein, D., De Groot, N., Segal, S., Folman, R., & Hochberg, A. A. (1981). Synthesis and secretion of alkaline phosphatase in vitro from first-trimester and term human placentas. Biochemical Journal, 194(3), 857–866. https://doi.org/10.1042/bj1940857
Galski, H., S. E. Fridovich, D. Weinstein, N. De Groot, S. Segal, R. Folman, and A. A. Hochberg. “Synthesis and secretion of alkaline phosphatase in vitro from first-trimester and term human placentas.” Biochemical Journal 194, no. 3 (March 15, 1981): 857–66. https://doi.org/10.1042/bj1940857.
Galski H, Fridovich SE, Weinstein D, De Groot N, Segal S, Folman R, et al. Synthesis and secretion of alkaline phosphatase in vitro from first-trimester and term human placentas. Biochemical Journal. 1981 Mar 15;194(3):857–66.
Galski, H., et al. “Synthesis and secretion of alkaline phosphatase in vitro from first-trimester and term human placentas.” Biochemical Journal, vol. 194, no. 3, Portland Press Ltd., Mar. 1981, pp. 857–66. Crossref, doi:10.1042/bj1940857.
Galski H, Fridovich SE, Weinstein D, De Groot N, Segal S, Folman R, Hochberg AA. Synthesis and secretion of alkaline phosphatase in vitro from first-trimester and term human placentas. Biochemical Journal. Portland Press Ltd.; 1981 Mar 15;194(3):857–866.
Journal cover image

Published In

Biochemical Journal

DOI

ISSN

0264-6021

Publication Date

March 15, 1981

Volume

194

Issue

3

Start / End Page

857 / 866

Publisher

Portland Press Ltd.

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
  • 03 Chemical Sciences