Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.

Published

Journal Article

Exercise training benefits many organ systems and offers protection against metabolic disorders such as obesity and diabetes. Using the recently identified isoform of PGC1-α (PGC1-α4) as a discovery tool, we report the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure. Increasing circulating levels of Metrnl stimulates energy expenditure and improves glucose tolerance and the expression of genes associated with beige fat thermogenesis and anti-inflammatory cytokines. Metrnl stimulates an eosinophil-dependent increase in IL-4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Importantly, blocking Metrnl actions in vivo significantly attenuates chronic cold-exposure-induced alternative macrophage activation and thermogenic gene responses. Thus, Metrnl links host-adaptive responses to the regulation of energy homeostasis and tissue inflammation and has therapeutic potential for metabolic and inflammatory diseases.

Full Text

Duke Authors

Cited Authors

  • Rao, RR; Long, JZ; White, JP; Svensson, KJ; Lou, J; Lokurkar, I; Jedrychowski, MP; Ruas, JL; Wrann, CD; Lo, JC; Camera, DM; Lachey, J; Gygi, S; Seehra, J; Hawley, JA; Spiegelman, BM

Published Date

  • June 2014

Published In

Volume / Issue

  • 157 / 6

Start / End Page

  • 1279 - 1291

PubMed ID

  • 24906147

Pubmed Central ID

  • 24906147

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2014.03.065

Language

  • eng