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Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression.

Publication ,  Journal Article
Zaffiri, L; d'Ettorre, G; Ceccarelli, G; Andreotti, M; Marcellini, S; Giustini, N; Ascoli-Bartoli, T; Mastroianni, CM; Vella, S; Vullo, V
Published in: J Interferon Cytokine Res
January 2014

Interleukin-17 (IL-17) is a pro-inflammatory cytokine that is mainly produced by CD4+ T cells. The role of Th17 during the human immunodeficiency virus (HIV)-1 infection is still unclear, but HIV-1 infection can cause a preferential depletion of Th17 cells. It has been shown that IL-15 elicits IL-17 production from human peripheral blood mononuclear cells. We studied the effect of IL-15 stimulation in vitro on IL-17 production from CD4+ mononuclear cells of HIV-infected patients. We observed that IL-15 triggers, in a dose-dependent manner, IL-17 secretion. This effect was blocked by anti-IL-15 monoclonal antibody (P=0.01). Interestingly, IL-17 production was significantly lower in patients with detectable plasma viremia when compared with successfully treated HIV-infected patients (P=0.02) and healthy controls, respectively (P<0.001). We also noticed a significant difference in IL-17 production between naïve HIV-infected patients and patients with virological failure on combined antiretroviral therapy (cART) (P=0.02). Our results suggest that IL-15 can induce IL-17 production from peripheral CD4+ mononuclear cells of HIV-infected patients. Persistent HIV plasma viremia could cause a severe perturbation of IL-17 production from CD4+ mononuclear cells. IL-17 production in HIV-infected patients could be recovered through a sustained suppression of the viral replication in the peripheral blood through cART.

Duke Scholars

Published In

J Interferon Cytokine Res

DOI

EISSN

1557-7465

Publication Date

January 2014

Volume

34

Issue

1

Start / End Page

35 / 40

Location

United States

Related Subject Headings

  • Virus Replication
  • Interleukin-17
  • Interleukin-15
  • Immunology
  • Humans
  • HIV Infections
  • CD4-Positive T-Lymphocytes
  • Anti-HIV Agents
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

APA
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MLA
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Zaffiri, L., d’Ettorre, G., Ceccarelli, G., Andreotti, M., Marcellini, S., Giustini, N., … Vullo, V. (2014). Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression. J Interferon Cytokine Res, 34(1), 35–40. https://doi.org/10.1089/jir.2012.0011
Zaffiri, Lorenzo, Gabriella d’Ettorre, Giancarlo Ceccarelli, Mauro Andreotti, Sonia Marcellini, Noemi Giustini, Tommaso Ascoli-Bartoli, Claudio M. Mastroianni, Stefano Vella, and Vincenzo Vullo. “Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression.J Interferon Cytokine Res 34, no. 1 (January 2014): 35–40. https://doi.org/10.1089/jir.2012.0011.
Zaffiri L, d’Ettorre G, Ceccarelli G, Andreotti M, Marcellini S, Giustini N, et al. Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression. J Interferon Cytokine Res. 2014 Jan;34(1):35–40.
Zaffiri, Lorenzo, et al. “Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression.J Interferon Cytokine Res, vol. 34, no. 1, Jan. 2014, pp. 35–40. Pubmed, doi:10.1089/jir.2012.0011.
Zaffiri L, d’Ettorre G, Ceccarelli G, Andreotti M, Marcellini S, Giustini N, Ascoli-Bartoli T, Mastroianni CM, Vella S, Vullo V. Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression. J Interferon Cytokine Res. 2014 Jan;34(1):35–40.
Journal cover image

Published In

J Interferon Cytokine Res

DOI

EISSN

1557-7465

Publication Date

January 2014

Volume

34

Issue

1

Start / End Page

35 / 40

Location

United States

Related Subject Headings

  • Virus Replication
  • Interleukin-17
  • Interleukin-15
  • Immunology
  • Humans
  • HIV Infections
  • CD4-Positive T-Lymphocytes
  • Anti-HIV Agents
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences