Central role of interleukin-15 in human immunodeficiency virus (HIV)-infected patients with visceral leishmaniasis.

Journal Article (Journal Article)

To evaluate clinical and immunological parameters, interleukin (IL)-15 production and outcome of patients with visceral leishmaniasis (VL), including HIV positive patients, we analyzed 48 cases of VL. Clinical manifestations and response to therapy were similar in VL/HIV- and VL/HIV+ patients. However, relapses were more frequent in patients with HIV infection. Low levels of IL-15 concentrations were found in HIV+ patients without VL. These levels were comparable to concentrations obtained in healthy donors. We found a relationship between response to therapy and IL-15 levels. We found increased levels of IL-15 in VL/HIV- and VL/HIV+ patients with clinical and parasitological response to therapy. Our data demonstrate that VL in HIV-infected patients occurs in subjects with severe immunodeficiency and presents high rate of relapses. Low levels of IL-15 in illness patients and restored production in cured persons suggest that this cytokine could play a central role in immune responses during Leishmania/HIV co-infection.

Full Text

Duke Authors

Cited Authors

  • d'Ettorre, G; Ceccarelli, G; Carnevalini, M; Forcina, G; Zaffiri, L; Massetti, AP; Mastroianni, CM; Vullo, V

Published Date

  • August 2006

Published In

Volume / Issue

  • 99 / 1

Start / End Page

  • 83 - 87

PubMed ID

  • 16962979

International Standard Serial Number (ISSN)

  • 0001-706X

Digital Object Identifier (DOI)

  • 10.1016/j.actatropica.2006.08.002


  • eng

Conference Location

  • Netherlands