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Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery.

Publication ,  Journal Article
Ni, J; Chen, M; Zhang, Y; Li, R; Huang, J; Yeh, S
Published in: Biochem Biophys Res Commun
January 10, 2003

Several epidemiological studies have demonstrated that vitamin E is a chemopreventative agent for prostate cancer. alpha-Tocopheryl succinate (VES), a derivative of vitamin E, effectively modulates prostate cancer cell growth. However, little is known about the mechanisms regarding this action. Here we show that VES causes human prostate cancer cell LNCaP arrest at G1 phase. This effect is accomplished through VES significantly decreasing expression of the cell cycle regulatory proteins cyclin D1, D3, and E, cdk2 and 4, but not cdk6. Furthermore, VES reduces cdk4 kinase activity, Rb phosphorylation, and cyclin E mRNA expression. Recently there is increasing interest in the protective effect of the VES and selenium combination on prostate cancer. Here we show that VES and selenium work through different mechanisms to exert their inhibitory effects on prostate cancer cells. Taken together, our studies suggest that VES-mediated prostate cancer cell G1/S arrest is a consequence of the regulation of multiple molecules of the cell cycle regulatory machinery.

Duke Scholars

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Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

January 10, 2003

Volume

300

Issue

2

Start / End Page

357 / 363

Location

United States

Related Subject Headings

  • Vitamin E
  • Tumor Cells, Cultured
  • Transcription Factors
  • Tocopherols
  • Selenomethionine
  • Retinoblastoma Protein
  • RNA, Messenger
  • Prostatic Neoplasms
  • Male
  • Humans
 

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Ni, J., Chen, M., Zhang, Y., Li, R., Huang, J., & Yeh, S. (2003). Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. Biochem Biophys Res Commun, 300(2), 357–363. https://doi.org/10.1016/s0006-291x(02)02851-6
Ni, Jing, Ming Chen, Yu Zhang, Rongshan Li, Jiaoti Huang, and Shuyuan Yeh. “Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery.Biochem Biophys Res Commun 300, no. 2 (January 10, 2003): 357–63. https://doi.org/10.1016/s0006-291x(02)02851-6.
Ni J, Chen M, Zhang Y, Li R, Huang J, Yeh S. Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. Biochem Biophys Res Commun. 2003 Jan 10;300(2):357–63.
Ni, Jing, et al. “Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery.Biochem Biophys Res Commun, vol. 300, no. 2, Jan. 2003, pp. 357–63. Pubmed, doi:10.1016/s0006-291x(02)02851-6.
Ni J, Chen M, Zhang Y, Li R, Huang J, Yeh S. Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. Biochem Biophys Res Commun. 2003 Jan 10;300(2):357–363.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

January 10, 2003

Volume

300

Issue

2

Start / End Page

357 / 363

Location

United States

Related Subject Headings

  • Vitamin E
  • Tumor Cells, Cultured
  • Transcription Factors
  • Tocopherols
  • Selenomethionine
  • Retinoblastoma Protein
  • RNA, Messenger
  • Prostatic Neoplasms
  • Male
  • Humans