Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era.

Journal Article (Journal Article;Review)

Stereotactic body radiation therapy (SBRT) utilizing a small number of high-dose radiation therapy fractions continues to expand in clinical application. Although many approaches have been proposed to radiosensitize tumors with conventional fractionation, how these radiosensitizers will translate to SBRT remains largely unknown. Here, we review our current understanding of how SBRT eradicates tumors, including the potential contributions of endothelial cell death and immune system activation. In addition, we identify several new opportunities for radiosensitization generated by the move toward high dose per fraction radiation therapy.

Full Text

Duke Authors

Cited Authors

  • Moding, EJ; Mowery, YM; Kirsch, DG

Published Date

  • July 2016

Published In

Volume / Issue

  • 22 / 4

Start / End Page

  • 267 - 273

PubMed ID

  • 27441746

Pubmed Central ID

  • PMC4957656

Electronic International Standard Serial Number (EISSN)

  • 1540-336X

Digital Object Identifier (DOI)

  • 10.1097/PPO.0000000000000203

Language

  • eng

Conference Location

  • United States