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[Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease.

Publication ,  Journal Article
Allen, TM; Anderson, LM; Rothman, JA; Bonner, MJ
Published in: Child Neuropsychol
November 2017

Research consistently indicates that children with sickle cell disease (SCD) face multiple risk factors for neurocognitive impairment. Despite this, no empirical research to date has examined the impact of neurocognitive functioning on quality of life for this pediatric group. Thus, the current study aims to examine the relationship between executive functioning and quality of life in a sample of children with SCD and further explore psychosocial and family/caregiver resources as moderators of this relationship. A total of 45 children with SCD aged 8 to 16 years and their caregivers completed measures of quality of life, behavioral ratings of executive functioning, and psychosocial functioning. Hierarchical linear regression models were utilized to determine the impact of executive functioning on quality of life and further test the interaction effects of proposed moderating variables. Controlling for age, pain, and socioeconomic status (SES), executive functioning was found to significantly predict child- and parent-reported quality of life among youth with SCD. Psychosocial resources of the primary caregiver or family was not found to moderate the relationship between executive functioning and quality of life. These results provide the first empirical evidence that lower executive skills negatively predict quality of life for children with SCD, supporting clinical and research efforts which aim to establish efficacious interventions that target cognitive decrements within this pediatric population.

Duke Scholars

Published In

Child Neuropsychol

DOI

EISSN

1744-4136

Publication Date

November 2017

Volume

23

Issue

8

Start / End Page

889 / 906

Location

England

Related Subject Headings

  • Quality of Life
  • Operations Research
  • Male
  • Humans
  • Female
  • Executive Function
  • Child
  • Anemia, Sickle Cell
  • Adolescent
  • 5201 Applied and developmental psychology
 

Citation

APA
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ICMJE
MLA
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Allen, T. M., Anderson, L. M., Rothman, J. A., & Bonner, M. J. (2017). [Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease. Child Neuropsychol, 23(8), 889–906. https://doi.org/10.1080/09297049.2016.1205011
Allen, Taryn M., Lindsay M. Anderson, Jennifer A. Rothman, and Melanie J. Bonner. “[Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease.Child Neuropsychol 23, no. 8 (November 2017): 889–906. https://doi.org/10.1080/09297049.2016.1205011.
Allen TM, Anderson LM, Rothman JA, Bonner MJ. [Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease. Child Neuropsychol. 2017 Nov;23(8):889–906.
Allen, Taryn M., et al. “[Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease.Child Neuropsychol, vol. 23, no. 8, Nov. 2017, pp. 889–906. Pubmed, doi:10.1080/09297049.2016.1205011.
Allen TM, Anderson LM, Rothman JA, Bonner MJ. [Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease. Child Neuropsychol. 2017 Nov;23(8):889–906.

Published In

Child Neuropsychol

DOI

EISSN

1744-4136

Publication Date

November 2017

Volume

23

Issue

8

Start / End Page

889 / 906

Location

England

Related Subject Headings

  • Quality of Life
  • Operations Research
  • Male
  • Humans
  • Female
  • Executive Function
  • Child
  • Anemia, Sickle Cell
  • Adolescent
  • 5201 Applied and developmental psychology