A new front in cell invasion: The invadopodial membrane.

Journal Article (Review;Journal Article)

Invadopodia are F-actin-rich membrane protrusions that breach basement membrane barriers during cell invasion. Since their discovery more than 30 years ago, invadopodia have been extensively investigated in cancer cells in vitro, where great advances in understanding their composition, formation, cytoskeletal regulation, and control of the matrix metalloproteinase MT1-MMP trafficking have been made. In contrast, few studies examining invadopodia have been conducted in vivo, leaving their physiological regulation unclear. Recent live-cell imaging and gene perturbation studies in C. elegans have revealed that invadopodia are formed with a unique invadopodial membrane, defined by its specialized lipid and associated protein composition, which is rapidly recycled through the endolysosome. Here, we provide evidence that the invadopodial membrane is conserved and discuss its possible functions in traversing basement membrane barriers. Discovery and examination of the invadopodial membrane has important implications in understanding the regulation, assembly, and function of invadopodia in both normal and disease settings.

Full Text

Duke Authors

Cited Authors

  • Hastie, EL; Sherwood, DR

Published Date

  • November 2016

Published In

Volume / Issue

  • 95 / 11

Start / End Page

  • 441 - 448

PubMed ID

  • 27402208

Pubmed Central ID

  • PMC5110387

Electronic International Standard Serial Number (EISSN)

  • 1618-1298

International Standard Serial Number (ISSN)

  • 0171-9335

Digital Object Identifier (DOI)

  • 10.1016/j.ejcb.2016.06.006


  • eng