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Effect of normal gait on in vivo tibiofemoral cartilage strains.

Publication ,  Journal Article
Lad, NK; Liu, B; Ganapathy, PK; Utturkar, GM; Sutter, EG; Moorman, CT; Garrett, WE; Spritzer, CE; DeFrate, LE
Published in: J Biomech
September 6, 2016

Altered cartilage loading is believed to be associated with osteoarthritis development. However, there are limited data regarding the influence of normal gait, an essential daily loading activity, on cartilage strains. In this study, 8 healthy subjects with no history of knee surgery or injury underwent magnetic resonance imaging of a single knee prior to and following a 20-min walking activity at approximately 1.1m/s. Bone and cartilage surfaces were segmented from these images and compiled into 3-dimensional models of the tibia, femur, and associated cartilage. Thickness changes were measured across a grid of evenly spaced points spanning the models of the articular surfaces. Averaged compartmental strains and local strains were then calculated. Overall compartmental strains after the walking activity were found to be significantly different from zero in all four tibiofemoral compartments, with tibial cartilage strain being significantly larger than femoral cartilage strain. These results provide baseline data regarding the normal tibiofemoral cartilage strain response to gait. Additionally, the technique employed in this study has potential to be used as a "stress test" to understand how factors including age, weight, and injury influence tibiofemoral cartilage strain response, essential information in the development of potential treatment strategies for the prevention of osteoarthritis.

Duke Scholars

Published In

J Biomech

DOI

EISSN

1873-2380

Publication Date

September 6, 2016

Volume

49

Issue

13

Start / End Page

2870 / 2876

Location

United States

Related Subject Headings

  • Young Adult
  • Weight-Bearing
  • Tibia
  • Male
  • Magnetic Resonance Imaging
  • Knee Joint
  • Humans
  • Gait
  • Femur
  • Female
 

Citation

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ICMJE
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Lad, N. K., Liu, B., Ganapathy, P. K., Utturkar, G. M., Sutter, E. G., Moorman, C. T., … DeFrate, L. E. (2016). Effect of normal gait on in vivo tibiofemoral cartilage strains. J Biomech, 49(13), 2870–2876. https://doi.org/10.1016/j.jbiomech.2016.06.025
Lad, Nimit K., Betty Liu, Pramodh K. Ganapathy, Gangadhar M. Utturkar, E Grant Sutter, Claude T. Moorman, William E. Garrett, Charles E. Spritzer, and Louis E. DeFrate. “Effect of normal gait on in vivo tibiofemoral cartilage strains.J Biomech 49, no. 13 (September 6, 2016): 2870–76. https://doi.org/10.1016/j.jbiomech.2016.06.025.
Lad NK, Liu B, Ganapathy PK, Utturkar GM, Sutter EG, Moorman CT, et al. Effect of normal gait on in vivo tibiofemoral cartilage strains. J Biomech. 2016 Sep 6;49(13):2870–6.
Lad, Nimit K., et al. “Effect of normal gait on in vivo tibiofemoral cartilage strains.J Biomech, vol. 49, no. 13, Sept. 2016, pp. 2870–76. Pubmed, doi:10.1016/j.jbiomech.2016.06.025.
Lad NK, Liu B, Ganapathy PK, Utturkar GM, Sutter EG, Moorman CT, Garrett WE, Spritzer CE, DeFrate LE. Effect of normal gait on in vivo tibiofemoral cartilage strains. J Biomech. 2016 Sep 6;49(13):2870–2876.
Journal cover image

Published In

J Biomech

DOI

EISSN

1873-2380

Publication Date

September 6, 2016

Volume

49

Issue

13

Start / End Page

2870 / 2876

Location

United States

Related Subject Headings

  • Young Adult
  • Weight-Bearing
  • Tibia
  • Male
  • Magnetic Resonance Imaging
  • Knee Joint
  • Humans
  • Gait
  • Femur
  • Female