State of the art: von Willebrand disease.


Journal Article (Review)

The State of the Art in von Willebrand disease (VWD) has been impacted not only by discoveries in the field of haemostasis, but also by changes in practice in other fields. The development of bleeding assessment tools has led to the clarification of bleeding symptoms and phenotype in VWD. New discoveries in the biology and genetics of von Willebrand factor (VWF) are challenging our existing diagnostics and classification(s). An improved understanding of reproductive physiology and the pathology of VWD along with changing obstetric, gynaecologic and haemostatic therapies necessitate an evolving response to the care of women with VWD. The survival of patients with autoimmune disease, malignancies and congenital heart disease along with increasing use of circulatory support devices and extracorporeal membrane oxygenation is increasing the prevalence of acquired von Willebrand syndrome. In each of these challenges, there are opportunities to improve the care of our patients with VWD.

Full Text

Duke Authors

Cited Authors

  • James, AH; Eikenboom, J; Federici, AB

Published Date

  • July 2016

Published In

Volume / Issue

  • 22 Suppl 5 /

Start / End Page

  • 54 - 59

PubMed ID

  • 27405677

Pubmed Central ID

  • 27405677

Electronic International Standard Serial Number (EISSN)

  • 1365-2516

Digital Object Identifier (DOI)

  • 10.1111/hae.12984


  • eng

Conference Location

  • England